Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFKB2_HUMAN
Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [Source:HGNC Symbol;Acc:7795]
Location:chr10 q24.32
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S277AFGDFsPTDVHHPRD
S866EVKEDsAYGSQPhosphoSitePlus; HPRD
S869DSAYGsQSVEQMAP3K14HPRD
S23FKLNSsIVEPKPhosphoSitePlus; HPRD; phosphoELM
S161RQRLRsRPQGLRHDPhosphoSitePlus
S715TSDSDsDSEGPPhosphoSitePlus; RegPhos
S870DSAYGsQSVEQNIKRegPhos
Y285DVHKQyAIVFRPhosphoSitePlus
S865EVKEDsAYGSQMAP3K14HPRD
S866EVKEDsAYGSQNIK(MAP3K14RegPhos
S762PLTPPsPAGPGHPRD
T859DKLPStAEVKEPhosphoSitePlus
S99DLVTHsDPPRARHDPhosphoSitePlus
T811TYRQTtSPSGSHPRD
S717DSDSDsEGPEKPhosphoSitePlus; RegPhos
S123GICAVsVGPKDRHDPhosphoSitePlus
S870DSAYGsQSVEQMAP3K14phosphoELM
S222IHDSKsPGASNPhosphoSitePlus; HPRD; phosphoELM
T682GLGYPtLTRLLAnk_2PhosphoSitePlus
S707LCPLPsPPTSDPhosphoSitePlus
S866EVKEDsAYGSQNIKRegPhos
S115VGKQCsELGICRHDPhosphoSitePlus
S872AYGSQsVEQEAIKKa(IKK alphaRegPhos
S872AYGSQsVEQEAIKK_alphaphosphoELM
Y326KQFTYyPLVEDPhosphoSitePlus
T97EVDLVtHSDPPRHDPhosphoSitePlus
T759MEPPLtPPSPAHPRD
S858RDKLPsTAEVKPhosphoSitePlus
T429SAPSRtPQCEPPhosphoSitePlus; HPRD; phosphoELM
S866EVKEDsAYGSQMAP3K14phosphoELM
S22DFKLNsSIVEPHPRD; phosphoELM
S711PSPPTsDSDSDPhosphoSitePlus
Y868KEDSAyGSQSVPhosphoSitePlus
S870DSAYGsQSVEQNIK(MAP3K14RegPhos
S870DSAYGsQSVEQPhosphoSitePlus; HPRD
Y55GFRFRyGCEGPRHDPhosphoSitePlus
S713PPTSDsDSDSEPhosphoSitePlus; RegPhos
Y325SKQFTyYPLVEPhosphoSitePlus
S226KSPGAsNLKISHPRD
S816TSPSGsLLRSYHPRD
S108RAHAHsLVGKQRHDPhosphoSitePlus
S872AYGSQsVEQEAPhosphoSitePlus
S220QPIHDsKSPGAHPRD

Dephosphorylation site
NFKB2_HUMAN do not have dephosphorylation site.

Mutation site
NFKB2_HUMAN do not have mutation site.

Differential expressed protein
NFKB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFKB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K14_HUMANNFKB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
M4K4_HUMANNFKB2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANNFKB2_HUMANkinase -> substrateRegPhos
TF65_HUMANNFKB2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa04380Osteoclast differentiation
hsa05203Viral carcinogenesis
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05134Legionellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0033257Bcl3/NF-kappaB2 complexIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002268follicular dendritic cell differentiationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0048536spleen developmentIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0002467germinal center formationIEAbiological_process
GO:0005515protein bindingIPImolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23