Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ICAM1_HUMAN
Description:intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:5344]
Location:chr19 p13.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y501AGLSTyLYNRQphosphoELM
T521QAQKGtPMKPNPhosphoSitePlus; HPRD; phosphoELM
T530PNTQAtHPRD; phosphoELM; SysPTM
S323TKPEVsEGTEVHPRD
T527PMKPNtQATHPRD; phosphoELM
Y501AGLSTyLYNRQTMPhosphoSitePlus
S275FSAKAsVSVTAIg_2PhosphoSitePlus
T217FVLPAtPPQLVIg_2PhosphoSitePlus
Y512RKIKKyRLQQAPhosphoSitePlus; phosphoELM
T530PNTQAtPP___PhosphoSitePlus; SysPTM
Y207NTSAPyQLQTFPhosphoSitePlus
T211PYQLQtFVLPAPhosphoSitePlus
S223PPQLVsPRVLEIg_2PhosphoSitePlus

Dephosphorylation site
ICAM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264832L451FCOSMICSkin Cancer21984974
ENSP00000264832P311LCOSMICOvarian Cancer21720365
ENSP00000264832Y512HCOSMICHead and Neck Cancer21798893
ENSP00000264832P311LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264832Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.718646787
ENSP00000264832Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.318646787
ENSP00000264832Gastric CancerMetastasiscell lineDown0.3817022644
ENSP00000264832Gastric CancerMetastasiscell lineDown0.3817022644
ENSP00000264832Breast CancerMetastasiscell lineUp219321434
ENSP00000264832Ovarian CancerMetastasiscell lineDown0.1717892554

Hyperphosphorylation site
ICAM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NFAC2_HUMANICAM1_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANICAM1_HUMANTF -> target geneTRANSFAC
TF65_HUMANICAM1_HUMANTF -> target geneTRANSFAC
CEBPB_HUMANICAM1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ICAM1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010477response to sulfur dioxideIEAbiological_process
GO:0007159leukocyte cell-cell adhesionIMPbiological_process
GO:0031669cellular response to nutrient levelsIEAbiological_process
GO:0002291T cell activation via T cell receptor contact withIMPbiological_process
GO:0002457T cell antigen processing and presentationIEAbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0001910regulation of leukocyte mediated cytotoxicityTASbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0071347cellular response to interleukin-1IEAbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0071312cellular response to alkaloidIEAbiological_process
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0050900leukocyte migrationIEPbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0007569cell agingIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0022614membrane to membrane dockingIEPbiological_process
GO:0043498cell surface bindingIEAmolecular_function
GO:0050776regulation of immune responseTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0034698response to gonadotropin stimulusIEAbiological_process
GO:0010212response to ionizing radiationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0071356cellular response to tumor necrosis factorIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0046688response to copper ionIEAbiological_process
GO:0007155cell adhesionIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0046813virion attachment, binding of host cell surface reIDAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032403protein complex bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0002693positive regulation of cellular extravasationIMPbiological_process
GO:0051856adhesion to symbiontIDAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0033627cell adhesion mediated by integrinIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0016337cell-cell adhesionIEAbiological_process
GO:0007159leukocyte cell-cell adhesionIEAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0001772immunological synapseIEAcellular_component
GO:0051926negative regulation of calcium ion transportIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0007157heterophilic cell-cell adhesionTASbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005886plasma membraneIEAcellular_component