Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL12B_HUMAN
Description:interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Source:HGNC Symbol;Acc:5970]
Location:chr5 q33.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S162KSSRGsSDPQGHPRD
S163SSRGSsDPQGVIL12p40_CPhosphoSitePlus
S163SSRGSsDPQGVHPRD
Y314RAQDRyYSSSWfn3PhosphoSitePlus
S162KSSRGsSDPQGIL12p40_CPhosphoSitePlus

Dephosphorylation site
IL12B_HUMAN do not have dephosphorylation site.

Mutation site
IL12B_HUMAN do not have mutation site.

Differential expressed protein
IL12B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL12B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
REL_HUMANIL12B_HUMANTF -> target geneTRANSFAC
ETS2_HUMANIL12B_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL12B_HUMANTF -> target geneTRANSFAC
SPI1_HUMANIL12B_HUMANTF -> target geneTRANSFAC
IRF2_HUMANIL12B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IL12B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0005125cytokine activityIDAmolecular_function
GO:0034105positive regulation of tissue remodelingICbiological_process
GO:0002862negative regulation of inflammatory response to anIEAbiological_process
GO:2000330positive regulation of T-helper 17 cell lineage coISSbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005125cytokine activityIEAmolecular_function
GO:0042102positive regulation of T cell proliferationIDAbiological_process
GO:0042832defense response to protozoanIEAbiological_process
GO:0034393positive regulation of smooth muscle cell apoptotiIDAbiological_process
GO:0005615extracellular spaceTAScellular_component
GO:0043514interleukin-12 complexIEAcellular_component
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0016477cell migrationIDAbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0019953sexual reproductionTASbiological_process
GO:0032816positive regulation of natural killer cell activatIDAbiological_process
GO:0045519interleukin-23 receptor bindingIDAmolecular_function
GO:0010535positive regulation of activation of JAK2 kinase aIDAbiological_process
GO:0002827positive regulation of T-helper 1 type immune respISSbiological_process
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0042520positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0045785positive regulation of cell adhesionIDAbiological_process
GO:0071346cellular response to interferon-gammaIEAbiological_process
GO:0042035regulation of cytokine biosynthetic processTASbiological_process
GO:0042093T-helper cell differentiationIDAbiological_process
GO:2000318positive regulation of T-helper 17 type immune resISSbiological_process
GO:0032733positive regulation of interleukin-10 productionIDAbiological_process
GO:0042510regulation of tyrosine phosphorylation of Stat1 prIDAbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIDAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0001916positive regulation of T cell mediated cytotoxicitIEAbiological_process
GO:0032725positive regulation of granulocyte macrophage coloIDAbiological_process
GO:0030101natural killer cell activationIDAbiological_process
GO:0032819positive regulation of natural killer cell prolifeIDAbiological_process
GO:0002230positive regulation of defense response to virus bISSbiological_process
GO:0051135positive regulation of NK T cell activationIDAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0001916positive regulation of T cell mediated cytotoxicitISSbiological_process
GO:0045672positive regulation of osteoclast differentiationIDAbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0032740positive regulation of interleukin-17 productionIDAbiological_process
GO:0070743interleukin-23 complexIDAcellular_component
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0042164interleukin-12 alpha subunit bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007050cell cycle arrestIDAbiological_process
GO:0032700negative regulation of interleukin-17 productionIDAbiological_process
GO:0002860positive regulation of natural killer cell mediateIDAbiological_process
GO:0002230positive regulation of defense response to virus bIEAbiological_process
GO:0032729positive regulation of interferon-gamma productionIDAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0032693negative regulation of interleukin-10 productionIMPbiological_process
GO:0032760positive regulation of tumor necrosis factor produIMPbiological_process
GO:0044130negative regulation of growth of symbiont in hostIEAbiological_process
GO:0002827positive regulation of T-helper 1 type immune respIEAbiological_process
GO:0042088T-helper 1 type immune responseTASbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0010224response to UV-BIDAbiological_process
GO:0005143interleukin-12 receptor bindingTASmolecular_function
GO:0050671positive regulation of lymphocyte proliferationIDAbiological_process
GO:0042095interferon-gamma biosynthetic processTASbiological_process
GO:0043382positive regulation of memory T cell differentiatiISSbiological_process
GO:0005126cytokine receptor bindingIEAmolecular_function
GO:0042346positive regulation of NF-kappaB import into nucleTASbiological_process
GO:0050829defense response to Gram-negative bacteriumIDAbiological_process
GO:0045078positive regulation of interferon-gamma biosynthetTASbiological_process
GO:0008083growth factor activityIDAmolecular_function
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0051142positive regulation of NK T cell proliferationIDAbiological_process
GO:0032735positive regulation of interleukin-12 productionIDAbiological_process
GO:0042104positive regulation of activated T cell proliferatIDAbiological_process
GO:0043514interleukin-12 complexIDAcellular_component
GO:0005737cytoplasmIEAcellular_component