| UniProt/SwissProt ID: | RAGE_HUMAN |
| Description: | advanced glycosylation end product-specific receptor [Source:HGNC Symbol;Acc:320] |
| Location: | chrHSCHR6_MHC_MANN p |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S391 | AELNQsEEPEA | PhosphoSitePlus | |
| S399 | PEAGEsSTGGP | PhosphoSitePlus | |
| Dephosphorylation site |
| RAGE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364217 | L388M | COSMIC | Breast Cancer | |
| Differential expressed protein |
| RAGE_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAGE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BMPR2_HUMAN | RAGE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAGE_HUMAN | CSK22_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | RAGE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PLK1_HUMAN | RAGE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAGE_HUMAN | MK07_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR1_HUMAN | RAGE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAGE_HUMAN | SMAD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAGE_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAGE_HUMAN | SOX10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RAGE_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0050930 | induction of positive chemotaxis | IEA | biological_process |
| GO:0031175 | neuron projection development | IGI | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | IDA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0009611 | response to wounding | TAS | biological_process |