Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MP2K5_HUMAN
Description:mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:6845]
Location:chr15 q23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S142SDSLPsNSLKKMAPK7phosphoELM
S142SDSLPsNSLKKErk5(MAPK7RegPhos
T315NSIAKtYVGTNPkinasePhosphoSitePlus
S149SLKKSsAELKKErk5(MAPK7RegPhos
S149SLKKSsAELKKPhosphoSitePlus
T315NSIAKtYVGTNHPRD; phosphoELM; RegPhos
S137SSPAVsDSLPSMAPK7phosphoELM
S132GPSQHsSPAVSHPRD
S129TRAGPsQHSSPErk5(MAPK7RegPhos
S148NSLKKsSAELKHPRD
S142SDSLPsNSLKKPhosphoSitePlus; HPRD
S149SLKKSsAELKKMAPK7phosphoELM
T71DGDRItVRSDEPB1PhosphoSitePlus
S311TQLVNsIAKTYHPRD; phosphoELM; RegPhos
S137SSPAVsDSLPSErk5(MAPK7RegPhos
S137SSPAVsDSLPSPhosphoSitePlus
S129TRAGPsQHSSPMAPK7phosphoELM
S129TRAGPsQHSSPPhosphoSitePlus
S311TQLVNsIAKTYPkinasePhosphoSitePlus
S133PSQHSsPAVSDPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
MP2K5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000178640H336DBIOMARTBreast Cancer21930507, 21930502
ENSP00000178640Q445ECOSMICGastric Cancer21097718
ENSP00000378859H336DBIOMARTBreast Cancer21930507, 21930502
ENSP00000378859G246VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MP2K5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MP2K5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK07_HUMANMP2K5_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMP2K5_HUMANkinase -> substrateRegPhos
MP2K5_HUMANMK07_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04540Gap junction
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051247positive regulation of protein metabolic processISSbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0071499cellular response to laminar fluid shear stressTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0090051negative regulation of cell migration involved in IEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0060761negative regulation of response to cytokine stimulIEAbiological_process
GO:0051247positive regulation of protein metabolic processIEAbiological_process
GO:2000342negative regulation of chemokine (C-X-C motif) ligIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000187activation of MAPK activityIEAbiological_process
GO:0070375ERK5 cascadeIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0045415negative regulation of interleukin-8 biosynthetic IEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005819spindleIEAcellular_component
GO:0034115negative regulation of heterotypic cell-cell adhesIEAbiological_process


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