| UniProt/SwissProt ID: | TF3C3_HUMAN |
| Description: | general transcription factor IIIC, polypeptide 3, 102kDa [Source:HGNC Symbol;Acc:4666] |
| Location: | chr2 q33.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y453 | VCSERyNLAVV | Apc3 | PhosphoSitePlus |
| Y301 | MAKSYyEANDV | Apc3 | PhosphoSitePlus |
| S592 | YLIKVsRDKIS | PhosphoSitePlus | |
| Y686 | NFRKAyNYIRI | PhosphoSitePlus | |
| Y246 | TKALKyEPTNV | TPR_2 | PhosphoSitePlus |
| T377 | APENVtCTIPD | PhosphoSitePlus | |
| Y471 | LKALGyMERAA | Apc3 | PhosphoSitePlus |
| T188 | YEPFStLAMIY | PhosphoSitePlus | |
| S187 | AYEPFsTLAMI | PhosphoSitePlus | |
| S43 | EKGKLsAEENP | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| TF3C3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263956 | D601E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263956 | E111* | COSMIC | Pancreatic Cancer | ENSP00000263956 | S604P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263956 | R474G | COSMIC | Breast Cancer | 20393555 |
| Differential expressed protein |
| TF3C3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TF3C3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK07_HUMAN | TF3C3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TF3C3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0042797 | tRNA transcription from RNA polymerase III promote | IC | biological_process |
| GO:0003677 | DNA binding | IC | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IC | biological_process |
| GO:0006383 | transcription from RNA polymerase III promoter | IC | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000127 | transcription factor TFIIIC complex | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042791 | 5S class rRNA transcription from RNA polymerase II | IC | biological_process |