Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AFAD_HUMAN
Description:myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 [Source:HGNC Symbol;Acc:7137]
Location:chr6 q27
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S561DSDRVsSASSTPhosphoSitePlus; HPRD
S1698EPPSPsPAPGAPhosphoSitePlus
S1799RQRLFsQGQDVPhosphoSitePlus
S1721KTQVLsPDSLFPhosphoSitePlus
S162FKRTLsKKEKKPhosphoSitePlus
Y1226IPTQTyTREYFPhosphoSitePlus
S1300AMDRKsDSDMWPhosphoSitePlus
S1090LLNQPsPMMQRphosphoELM; RegPhos
T1081ELMTRtSSVVTPDZPhosphoSitePlus
Y1213TYTREyFTFPARegPhos
Y986FEGADyESHLLPhosphoSitePlus
S1783DSPGSsGAPENPhosphoSitePlus
S562SDRVSsASSTAPhosphoSitePlus
S1779SQDADsPGSSGPhosphoSitePlus
S1201KITSVsTGNLCPhosphoSitePlus
Y1656RQEEGyYSRLEPhosphoSitePlus
S1774EKRSKsQDADSPhosphoSitePlus
Y1151LPWAEySEPKKPhosphoSitePlus
S1275QRVTRsQEELRPhosphoSitePlus; HPRD
T1499DLQYItVSKEEPhosphoSitePlus
S1126KPRPKsEGFELPhosphoSitePlus
S1317LDSSTsSQEHLHPRD
S424YRLQLsVTEVGPhosphoSitePlus; HPRD
T1489QQQPRtIERRDPhosphoSitePlus
T909TVAENtADELAPhosphoSitePlus
Y980GTWTIyFEGADPhosphoSitePlus
S1172RADHRsSPNVAPhosphoSitePlus; HPRD
S1083MTRTSsVVTLEPDZPhosphoSitePlus
S1658EEGYYsRLEAEPhosphoSitePlus
Y263KPNIPyKTILLRAPhosphoSitePlus
T1202ITSVStGNLCTPhosphoSitePlus
S1782ADSPGsSGAPEPhosphoSitePlus
S1182ANQPPsPGGKSPhosphoSitePlus; HPRD
T893TVAENtADELAphosphoELM; RegPhos
T1136LYNNStQNGSPPhosphoSitePlus
T1317VTPAStLTKSGRegPhos
S541TTRLDsDRVSSRegPhos
S1184KITSVsTGNLCphosphoELM; RegPhos
Y375ADGSGyGSTLPPhosphoSitePlus
S1140STQNGsPESPQPhosphoSitePlus; HPRD
S564RVSSAsSTAERPhosphoSitePlus; HPRD
T1330SSKSVtPASTLHPRD
S1107LLNQPsPMMQRPhosphoSitePlus; HPRD
T1211CTEEQtPPPRPPhosphoSitePlus
S216FTRTIsNPEVVPhosphoSitePlus; HPRD
S1501QYITVsKEELSPhosphoSitePlus
S1083MTRTSsVVTLEHPRD
Y1497RRDLQyITVSKPhosphoSitePlus
Y1692PLPRDyEPPSPPhosphoSitePlus
Y1419EHQRWyEKEKAPhosphoSitePlus
Y1252NQWPNyEEKPHPhosphoSitePlus
T893TVAENtADELABCRRegPhos
T1352AAIPAtPVAVSPhosphoSitePlus
S1155RADHRsSPNVAphosphoELM; RegPhos
Y1285REDKAyQLERHPhosphoSitePlus
S1187SPGGKsAYASGPhosphoSitePlus
Y1219PRPEAyPIPTQPhosphoSitePlus
S1455NPAPFsPLTAQPhosphoSitePlus
S557TTRLDsDRVSSPhosphoSitePlus
S1258QRVTRsQEELRRegPhos
Y203LAAEVyKDMPEPhosphoSitePlus; HPRD
Y253GTLRIyADSLKRAPhosphoSitePlus
Y94PKYSLyEVHVSRAPhosphoSitePlus
Y1230TYTREyFTFPAPhosphoSitePlus; HPRD
T1232TREYFtFPASKPhosphoSitePlus; HPRD
T249PDSGGtLRIYARAPhosphoSitePlus
S672VNKMVsMMEGVPhosphoSitePlus
S1156ADHRSsPNVANphosphoELM; RegPhos
S1696DYEPPsPSPAPPhosphoSitePlus
T1207TGNLCtEEQTPPhosphoSitePlus
S1512SGDSLsPDPWKPhosphoSitePlus; HPRD
Y1657QEEGYySRLEAPhosphoSitePlus
T1194YASGTtAKITSPhosphoSitePlus
Y94PKYSLyEVHVSHPRD; phosphoELM
Y1229QTYTReYFTFPHPRD
Y1132EGFELyNNSTQPhosphoSitePlus
Y295ENPKDyCIARVRAPhosphoSitePlus
T160QNFKRtLSKKEPhosphoSitePlus
T566SSASStAERGMPhosphoSitePlus
Y1189GGKSAyASGTTPhosphoSitePlus
S1173ADHRSsPNVANPhosphoSitePlus; HPRD
T1313SSKSVtPASTLRegPhos
S1143NGSPEsPQLPWPhosphoSitePlus
Y584EQQPDyRRQESPhosphoSitePlus
S1681EPPSPsPAPGAphosphoELM; RegPhos
S565VSSASsTAERGPhosphoSitePlus; HPRD
T1815ASRKLtELENEPhosphoSitePlus
S1165ANQPPsPGGKSphosphoELM; RegPhos

Dephosphorylation site
AFAD_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375956R1434*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
AFAD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AFAD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANAFAD_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANAFAD_HUMANkinase -> substrateRegPhos
BCR_HUMANAFAD_HUMANkinase -> substrateHPRD; RegPhos
RRAS2_HUMANAFAD_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa04520Adherens junction
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005911cell-cell junctionTAScellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0034332adherens junction organizationTASbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0030054cell junctionIDAcellular_component
GO:0007267cell-cell signalingTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0045177apical part of cellIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0005912adherens junctionIEAcellular_component
GO:0045216cell-cell junction organizationTASbiological_process
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008022protein C-terminus bindingTASmolecular_function
GO:0050839cell adhesion molecule bindingIEAmolecular_function


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