| UniProt/SwissProt ID: | AFAD_HUMAN |
| Description: | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 [Source:HGNC Symbol;Acc:7137] |
| Location: | chr6 q27 |
| Node attribute: | substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S561 | DSDRVsSASST | PhosphoSitePlus; HPRD | |
| S1698 | EPPSPsPAPGA | PhosphoSitePlus | |
| S1799 | RQRLFsQGQDV | PhosphoSitePlus | |
| S1721 | KTQVLsPDSLF | PhosphoSitePlus | |
| S162 | FKRTLsKKEKK | PhosphoSitePlus | |
| Y1226 | IPTQTyTREYF | PhosphoSitePlus | |
| S1300 | AMDRKsDSDMW | PhosphoSitePlus | |
| S1090 | LLNQPsPMMQR | phosphoELM; RegPhos | |
| T1081 | ELMTRtSSVVT | PDZ | PhosphoSitePlus |
| Y1213 | TYTREyFTFPA | RegPhos | |
| Y986 | FEGADyESHLL | PhosphoSitePlus | |
| S1783 | DSPGSsGAPEN | PhosphoSitePlus | |
| S562 | SDRVSsASSTA | PhosphoSitePlus | |
| S1779 | SQDADsPGSSG | PhosphoSitePlus | |
| S1201 | KITSVsTGNLC | PhosphoSitePlus | |
| Y1656 | RQEEGyYSRLE | PhosphoSitePlus | |
| S1774 | EKRSKsQDADS | PhosphoSitePlus | |
| Y1151 | LPWAEySEPKK | PhosphoSitePlus | |
| S1275 | QRVTRsQEELR | PhosphoSitePlus; HPRD | |
| T1499 | DLQYItVSKEE | PhosphoSitePlus | |
| S1126 | KPRPKsEGFEL | PhosphoSitePlus | |
| S1317 | LDSSTsSQEHL | HPRD | |
| S424 | YRLQLsVTEVG | PhosphoSitePlus; HPRD | |
| T1489 | QQQPRtIERRD | PhosphoSitePlus | |
| T909 | TVAENtADELA | PhosphoSitePlus | |
| Y980 | GTWTIyFEGAD | PhosphoSitePlus | |
| S1172 | RADHRsSPNVA | PhosphoSitePlus; HPRD | |
| S1083 | MTRTSsVVTLE | PDZ | PhosphoSitePlus |
| S1658 | EEGYYsRLEAE | PhosphoSitePlus | |
| Y263 | KPNIPyKTILL | RA | PhosphoSitePlus |
| T1202 | ITSVStGNLCT | PhosphoSitePlus | |
| S1782 | ADSPGsSGAPE | PhosphoSitePlus | |
| S1182 | ANQPPsPGGKS | PhosphoSitePlus; HPRD | |
| T893 | TVAENtADELA | phosphoELM; RegPhos | |
| T1136 | LYNNStQNGSP | PhosphoSitePlus | |
| T1317 | VTPAStLTKSG | RegPhos | |
| S541 | TTRLDsDRVSS | RegPhos | |
| S1184 | KITSVsTGNLC | phosphoELM; RegPhos | |
| Y375 | ADGSGyGSTLP | PhosphoSitePlus | |
| S1140 | STQNGsPESPQ | PhosphoSitePlus; HPRD | |
| S564 | RVSSAsSTAER | PhosphoSitePlus; HPRD | |
| T1330 | SSKSVtPASTL | HPRD | |
| S1107 | LLNQPsPMMQR | PhosphoSitePlus; HPRD | |
| T1211 | CTEEQtPPPRP | PhosphoSitePlus | |
| S216 | FTRTIsNPEVV | PhosphoSitePlus; HPRD | |
| S1501 | QYITVsKEELS | PhosphoSitePlus | |
| S1083 | MTRTSsVVTLE | HPRD | |
| Y1497 | RRDLQyITVSK | PhosphoSitePlus | |
| Y1692 | PLPRDyEPPSP | PhosphoSitePlus | |
| Y1419 | EHQRWyEKEKA | PhosphoSitePlus | |
| Y1252 | NQWPNyEEKPH | PhosphoSitePlus | |
| T893 | TVAENtADELA | BCR | RegPhos |
| T1352 | AAIPAtPVAVS | PhosphoSitePlus | |
| S1155 | RADHRsSPNVA | phosphoELM; RegPhos | |
| Y1285 | REDKAyQLERH | PhosphoSitePlus | |
| S1187 | SPGGKsAYASG | PhosphoSitePlus | |
| Y1219 | PRPEAyPIPTQ | PhosphoSitePlus | |
| S1455 | NPAPFsPLTAQ | PhosphoSitePlus | |
| S557 | TTRLDsDRVSS | PhosphoSitePlus | |
| S1258 | QRVTRsQEELR | RegPhos | |
| Y203 | LAAEVyKDMPE | PhosphoSitePlus; HPRD | |
| Y253 | GTLRIyADSLK | RA | PhosphoSitePlus |
| Y94 | PKYSLyEVHVS | RA | PhosphoSitePlus |
| Y1230 | TYTREyFTFPA | PhosphoSitePlus; HPRD | |
| T1232 | TREYFtFPASK | PhosphoSitePlus; HPRD | |
| T249 | PDSGGtLRIYA | RA | PhosphoSitePlus |
| S672 | VNKMVsMMEGV | PhosphoSitePlus | |
| S1156 | ADHRSsPNVAN | phosphoELM; RegPhos | |
| S1696 | DYEPPsPSPAP | PhosphoSitePlus | |
| T1207 | TGNLCtEEQTP | PhosphoSitePlus | |
| S1512 | SGDSLsPDPWK | PhosphoSitePlus; HPRD | |
| Y1657 | QEEGYySRLEA | PhosphoSitePlus | |
| T1194 | YASGTtAKITS | PhosphoSitePlus | |
| Y94 | PKYSLyEVHVS | HPRD; phosphoELM | |
| Y1229 | QTYTReYFTFP | HPRD | |
| Y1132 | EGFELyNNSTQ | PhosphoSitePlus | |
| Y295 | ENPKDyCIARV | RA | PhosphoSitePlus |
| T160 | QNFKRtLSKKE | PhosphoSitePlus | |
| T566 | SSASStAERGM | PhosphoSitePlus | |
| Y1189 | GGKSAyASGTT | PhosphoSitePlus | |
| S1173 | ADHRSsPNVAN | PhosphoSitePlus; HPRD | |
| T1313 | SSKSVtPASTL | RegPhos | |
| S1143 | NGSPEsPQLPW | PhosphoSitePlus | |
| Y584 | EQQPDyRRQES | PhosphoSitePlus | |
| S1681 | EPPSPsPAPGA | phosphoELM; RegPhos | |
| S565 | VSSASsTAERG | PhosphoSitePlus; HPRD | |
| T1815 | ASRKLtELENE | PhosphoSitePlus | |
| S1165 | ANQPPsPGGKS | phosphoELM; RegPhos | |
| Dephosphorylation site |
| AFAD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000375956 | R1434* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| AFAD_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AFAD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCI_HUMAN | AFAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | AFAD_HUMAN | kinase -> substrate | RegPhos |
| BCR_HUMAN | AFAD_HUMAN | kinase -> substrate | HPRD; RegPhos |
| RRAS2_HUMAN | AFAD_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04530 | Tight junction |
| hsa04520 | Adherens junction |
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005911 | cell-cell junction | TAS | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0034332 | adherens junction organization | TAS | biological_process |
| GO:0005911 | cell-cell junction | IEA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0030054 | cell junction | IDA | cellular_component |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0005912 | adherens junction | IEA | cellular_component |
| GO:0045216 | cell-cell junction organization | TAS | biological_process |
| GO:0005913 | cell-cell adherens junction | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008022 | protein C-terminus binding | TAS | molecular_function |
| GO:0050839 | cell adhesion molecule binding | IEA | molecular_function |