UniProt/SwissProt ID: | PARD3_HUMAN |
Description: | par-3 partitioning defective 3 homolog (C. elegans) [Source:HGNC Symbol;Acc:16051] |
Location: | chr10 p11.21 |
Node attribute: | substrate; PPI(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
T481 | TSRDVtIGGSA | PDZ | PhosphoSitePlus |
S596 | VPLNDsGSAGL | PDZ | PhosphoSitePlus |
Y719 | ISHSLySGIEG | PhosphoSitePlus; HPRD | |
Y388 | SPDSQyIDNRS | PhosphoSitePlus; HPRD | |
T947 | DEGMEtLEEDT | PhosphoSitePlus | |
S837 | RTKQFsDASQL | PhosphoSitePlus | |
T534 | SLLRStKMEGT | PDZ | PhosphoSitePlus |
S1146 | VDSNRsTPSNH | PhosphoSitePlus | |
S25 | HMKVFsLIQQA | DUF3534 | PhosphoSitePlus |
S730 | LDESPsRNAAL | PhosphoSitePlus | |
Y1310 | EGPSNyDSYKK | PhosphoSitePlus | |
Y199 | KKDENyRSLPR | PhosphoSitePlus | |
S143 | LHVRRsSDPAL | DUF3534 | PhosphoSitePlus |
Y1177 | DRRRTySFEQP | PhosphoSitePlus; HPRD | |
S803 | AAISDsADCSL | HPRD; phosphoELM | |
T895 | LESLQtAVAEV | PhosphoSitePlus | |
S717 | RRISHsLYSGI | PhosphoSitePlus; phosphoELM | |
S604 | AGLGVsVKGNR | PDZ | PhosphoSitePlus |
S667 | LRRSMsTEGNK | PDZ | PhosphoSitePlus |
S201 | DENYRsLPRDT | PhosphoSitePlus | |
S695 | LKSPGsPPGPE | PhosphoSitePlus; HPRD; phosphoELM | |
S887 | LGLKKsSSLES | PhosphoSitePlus | |
S144 | HVRRSsDPALI | HPRD; phosphoELM | |
Y1269 | GSRNGyLGGHG | PhosphoSitePlus | |
T534 | SLLRStKMEGT | HPRD | |
S533 | VSLLRsTKMEG | PDZ | PhosphoSitePlus |
S485 | VTIGGsAPIYV | PDZ | PhosphoSitePlus |
S221 | DNARSsLSASH | PhosphoSitePlus | |
S529 | QEEVVsLLRST | PDZ | PhosphoSitePlus |
S924 | RGCNEsFRAAI | PhosphoSitePlus | |
S873 | DQKAGsPSRDV | PhosphoSitePlus; HPRD; phosphoELM | |
T175 | PTRWStTAGFL | PhosphoSitePlus; HPRD | |
Y1221 | QAQRQySSLPR | PhosphoSitePlus | |
S973 | DQPSHsLERQM | HPRD | |
Y489 | GSAPIyVKNIL | HPRD; phosphoELM | |
S1139 | RNSKPsPVDSN | PhosphoSitePlus | |
S665 | ETLRRsMSTEG | PDZ | PhosphoSitePlus |
S1261 | NPRYSsYQGSR | PhosphoSitePlus | |
Y1080 | ARERDyAEIQD | PhosphoSitePlus; HPRD | |
S370 | QYEQLsQSEKN | PhosphoSitePlus | |
S809 | ADCSLsPDVDP | PhosphoSitePlus; HPRD; phosphoELM | |
S715 | RERRIsHSLYS | PhosphoSitePlus; HPRD; phosphoELM | |
T1147 | DSNRStPSNHD | PhosphoSitePlus | |
S827 | GFGRQsMSEKR | PhosphoSitePlus | |
T579 | EDIVLtPDGTR | PhosphoSitePlus; HPRD | |
Y1313 | SNYDSyKKVQD | PhosphoSitePlus | |
S720 | SHSLYsGIEGL | PhosphoSitePlus; phosphoELM | |
S1335 | QDVPPsPSQVA | PhosphoSitePlus | |
S875 | KAGSPsRDVGP | HPRD | |
S852 | TRKSKsMDLGI | PhosphoSitePlus; HPRD; phosphoELM | |
T32 | IQQAVtRYRKA | DUF3534 | PhosphoSitePlus |
Y377 | SEKNNyYSSRF | PhosphoSitePlus | |
T1176 | EDRRRtYSFEQ | PhosphoSitePlus; HPRD | |
Y119 | SAFQPyQATSE | DUF3534 | PhosphoSitePlus |
S692 | CNELKsPGSPP | PhosphoSitePlus; HPRD; phosphoELM | |
S166 | SSEEPsRKNPT | PhosphoSitePlus | |
S144 | HVRRSsDPALI | DUF3534 | PhosphoSitePlus |
T668 | RRSMStEGNKR | PDZ | PhosphoSitePlus |
S1222 | AQRQYsSLPRQ | PhosphoSitePlus | |
Y378 | EKNNYySSRFS | PhosphoSitePlus | |
S881 | RDVGPsLGLKK | PhosphoSitePlus | |
S889 | LKKSSsLESLQ | PhosphoSitePlus; phosphoELM | |
Y933 | AIDKSyDKPAV | PhosphoSitePlus | |
Y1244 | SWEQNySPGEG | PhosphoSitePlus | |
S533 | VSLLRsTKMEG | HPRD | |
S598 | LNDSGsAGLGV | PDZ | PhosphoSitePlus |
Y489 | GSAPIyVKNIL | PDZ | PhosphoSitePlus |
S220 | RDNARsSLSAS | PhosphoSitePlus | |
S156 | LSTSVsDSNFS | PhosphoSitePlus | |
S143 | LHVRRsSDPAL | HPRD; phosphoELM | |
T1347 | LNRLQtPEKGR | PhosphoSitePlus | |
Y1104 | GGVSSyEGSMA | PhosphoSitePlus | |
S523 | DLVGKsQEEVV | PDZ | PhosphoSitePlus |
S1178 | RRRTYsFEQPW | PhosphoSitePlus | |
Y1127 | MMDALyAQVKK | PhosphoSitePlus; HPRD; phosphoELM | |
S962 | RSGREsVSTAS | PhosphoSitePlus | |
S380 | NNYYSsRFSPD | PhosphoSitePlus | |
S1312 | PSNYDsYKKVQ | PhosphoSitePlus | |
S807 | DSADCsLSPDV | HPRD | |
Y1098 | DDELMyGGVSS | PhosphoSitePlus | |
S383 | YSSRFsPDSQY | PhosphoSitePlus; HPRD; phosphoELM | |
S379 | KNNYYsSRFSP | PhosphoSitePlus | |
S386 | RFSPDsQYIDN | PhosphoSitePlus | |
Y1321 | VQDPSyAPPKG | PhosphoSitePlus | |
S174 | NPTRWsTTAGF | PhosphoSitePlus; HPRD | |
S728 | EGLDEsPSRNA | PhosphoSitePlus; HPRD; phosphoELM | |
S1337 | VPPSPsQVARL | PhosphoSitePlus | |
Dephosphorylation site |
PARD3_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000363908 | T648S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000363921 | R50G | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000363921 | T661S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000341844 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000363920 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000363926 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000311986 | T648S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000311986 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000340591 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000340591 | T661S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000363921 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000341844 | T661S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000363926 | T604S | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000363908 | L108F | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000363921 | R1156H | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000363920 | T661S | BIOMART | Breast Cancer | 21930507, 21930502 |
Differential expressed protein |
PARD3_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
PARD3_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
KPCI_HUMAN | PARD3_HUMAN | kinase -> substrate | KEGG |
PARD3_HUMAN | IGSF5_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04520 | Adherens junction |
hsa04530 | Tight junction |
hsa04144 | Endocytosis |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04062 | Chemokine signaling pathway |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0005829 | cytosol | TAS | cellular_component |
GO:0034329 | cell junction assembly | TAS | biological_process |
GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
GO:0005819 | spindle | IEA | cellular_component |
GO:0005913 | cell-cell adherens junction | IEA | cellular_component |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0043234 | protein complex | IEA | cellular_component |
GO:0030054 | cell junction | IEA | cellular_component |
GO:0032970 | regulation of actin filament-based process | IEA | biological_process |
GO:0006461 | protein complex assembly | TAS | biological_process |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISS | molecular_function |
GO:0012505 | endomembrane system | IEA | cellular_component |
GO:0044295 | axonal growth cone | IEA | cellular_component |
GO:0005912 | adherens junction | IEA | cellular_component |
GO:0006612 | protein targeting to membrane | IEA | biological_process |
GO:0005737 | cytoplasm | IEA | cellular_component |
GO:0030054 | cell junction | TAS | cellular_component |
GO:0043025 | neuronal cell body | IEA | cellular_component |
GO:0019903 | protein phosphatase binding | IEA | molecular_function |
GO:0070830 | tight junction assembly | IEA | biological_process |
GO:0045216 | cell-cell junction organization | TAS | biological_process |
GO:0007409 | axonogenesis | TAS | biological_process |
GO:0005923 | tight junction | ISS | cellular_component |
GO:0006612 | protein targeting to membrane | ISS | biological_process |
GO:0090162 | establishment of epithelial cell polarity | ISS | biological_process |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IEA | molecular_function |
GO:0000226 | microtubule cytoskeleton organization | IEA | biological_process |
GO:0045177 | apical part of cell | IEA | cellular_component |
GO:0005080 | protein kinase C binding | IEA | molecular_function |
GO:0032266 | phosphatidylinositol-3-phosphate binding | ISS | molecular_function |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0051642 | centrosome localization | IEA | biological_process |
GO:0090162 | establishment of epithelial cell polarity | IEA | biological_process |
GO:0044319 | wound healing, spreading of cells | IEA | biological_process |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0003383 | apical constriction | IEA | biological_process |
GO:0007205 | protein kinase C-activating G-protein coupled rece | TAS | biological_process |
GO:0007163 | establishment or maintenance of cell polarity | TAS | biological_process |
GO:0032266 | phosphatidylinositol-3-phosphate binding | IEA | molecular_function |
GO:0005938 | cell cortex | IEA | cellular_component |
GO:0005911 | cell-cell junction | IEA | cellular_component |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IEA | molecular_function |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | ISS | molecular_function |
GO:0070830 | tight junction assembly | ISS | biological_process |
GO:0008356 | asymmetric cell division | TAS | biological_process |
GO:0007049 | cell cycle | IEA | biological_process |
GO:0005911 | cell-cell junction | ISS | cellular_component |
GO:0060341 | regulation of cellular localization | IEA | biological_process |