| UniProt/SwissProt ID: | PIR_HUMAN |
| Description: | pirin (iron-binding nuclear protein) [Source:HGNC Symbol;Acc:30048] |
| Location: | chrX p22.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y131 | MVEPQyQELKS | PhosphoSitePlus | |
| T8 | SSKKVtLSVLS | HPRD | |
| Dephosphorylation site |
| PIR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000369786 | K46E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369786 | D89H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000369785 | K46E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369785 | D89H | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000369786 | Non-small cell lung carcinoma | Metastasis | cell line | Down | 17537172 | |
| Hyperphosphorylation site |
| PIR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCI_HUMAN | PIR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | PIR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PIR_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003712 | transcription cofactor activity | TAS | molecular_function |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0046872 | metal ion binding | IDA | molecular_function |
| GO:0008127 | quercetin 2,3-dioxygenase activity | IDA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030224 | monocyte differentiation | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030099 | myeloid cell differentiation | IEA | biological_process |