| UniProt/SwissProt ID: | SHPS1_HUMAN |
| Description: | signal-regulatory protein alpha [Source:HGNC Symbol;Acc:9662] |
| Location: | chr20 p13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y495 | PSFSEyASVQV | JAK2 | RegPhos |
| Y496 | PSFSEyASVQV | PhosphoSitePlus; HPRD | |
| T469 | SEDTLtYADLD | PhosphoSitePlus | |
| Y453 | NNHTEyASIQT | PhosphoSitePlus | |
| Y429 | TNDITyADLNL | PhosphoSitePlus | |
| Y428 | TNDITyADLNL | Tyr-kinases | RegPhos |
| S204 | DPVGEsVSYSI | C1-set | PhosphoSitePlus |
| S192 | NGNELsDFQTN | C1-set | PhosphoSitePlus |
| Y495 | PSFSEyASVQV | Tyr-kinases | RegPhos |
| T428 | DTNDItYADLN | PhosphoSitePlus | |
| S464 | SPQPAsEDTLT | PhosphoSitePlus | |
| Y496 | PSFSEyASVQV | JAK2 | HPRD |
| T467 | PASEDtLTYAD | PhosphoSitePlus | |
| S494 | PEPSFsEYASV | PhosphoSitePlus | |
| Y470 | EDTLTyADLDM | PhosphoSitePlus | |
| Y452 | NNHTEyASIQT | Tyr-kinases | RegPhos |
| Y469 | EDTLTyADLDM | Tyr-kinases | RegPhos |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y453 | EPNNHTEyASIQTSP | PTPN11 | HPRD |
| Y453 | EPNNHTEyASIQTSP | PTPN6 | HPRD |
| Y496 | PEPSFSEyASVQVPR | PTPN11 | HPRD |
| Y429 | QDTNDITyADLNLPK | PTPN11 | HPRD |
| Y470 | ASEDTLTyADLDMVH | PTPN11 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000351621 | V302I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000348307 | N100D | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000351621 | V302I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348307 | V302I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348307 | V302I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000351621 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000351621 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 16051329 | ENSP00000351621 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 19771267 |
| Hyperphosphorylation site |
| SHPS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK2_HUMAN | SHPS1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PTN11_HUMAN | SHPS1_HUMAN | phosphatase -> substrate | HPRD |
| PTN6_HUMAN | SHPS1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |