Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GHR_HUMAN
Description:growth hormone receptor [Source:HGNC Symbol;Acc:4263]
Location:chr5 p13.1
Node attribute:substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y218TSVPVySLKVDfn3PhosphoSitePlus
Y566NQEDIyITTESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y332AIHDSyKPEFHJAK2phosphoELM; RegPhos
S368DRLLSsDHEKSPhosphoSitePlus
T357EPDEKtEESDTPhosphoSitePlus
Y487SNIDFyAQVSDHPRD; RegPhos
Y226KVDKEyEVRVRfn3PhosphoSitePlus
Y627LSSCGyVSTDQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y332AIHDSyKPEFHHPRD; RegPhos
Y534LMDNAyFCEADPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S367TDRLLsSDHEKPhosphoSitePlus
Y487SNIDFyAQVSDJAK2phosphoELM; RegPhos

Dephosphorylation site
GHR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000230882V343ICOSMICLung Cancer
ENSP00000230882G274ECOSMICMelanoma21499247
ENSP00000230882M206VCOSMICLung Cancer20668451
ENSP00000230882Q253*COSMICLung Cancer20668451
ENSP00000230882V136LCOSMICRenal Cancer20054297
ENSP00000230882C390SCOSMICOvarian Cancer21720365

Differential expressed protein
GHR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GHR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOMA_HUMANGHR_HUMANligand -> receptorHPMR
ZAGL2_HUMANGHR_HUMANkinase -> substrateRegPhos
JAK2_HUMANGHR_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SOM2_HUMANGHR_HUMANotherKEGG
ERCC8_HUMANGHR_HUMANotherKEGG
SOMA_HUMANGHR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050731positive regulation of peptidyl-tyrosine phosphoryISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006549isoleucine metabolic processISSbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0007259JAK-STAT cascadeIEAbiological_process
GO:0032870cellular response to hormone stimulusIMPbiological_process
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0046427positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0070195growth hormone receptor complexIDAcellular_component
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0031623receptor internalizationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070555response to interleukin-1IEAbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0006600creatine metabolic processISSbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0032094response to foodIEAbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0046898response to cycloheximideIDAbiological_process
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0016021integral to membraneIDAcellular_component
GO:0042523positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0006105succinate metabolic processISSbiological_process
GO:1901215negative regulation of neuron deathIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0044236multicellular organismal metabolic processIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0006631fatty acid metabolic processISSbiological_process
GO:0042977activation of JAK2 kinase activityIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0006573valine metabolic processISSbiological_process
GO:0006101citrate metabolic processISSbiological_process
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0004903growth hormone receptor activityIEAmolecular_function
GO:0042976activation of Janus kinase activityIEAbiological_process
GO:0060396growth hormone receptor signaling pathwayIEAbiological_process
GO:0040018positive regulation of multicellular organism growIMPbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0019898extrinsic to membraneIEAcellular_component
GO:0000255allantoin metabolic processISSbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0042517positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0060351cartilage development involved in endochondral bonIEAbiological_process
GO:0070064proline-rich region bindingISSmolecular_function
GO:0019838growth factor bindingIPImolecular_function
GO:0006107oxaloacetate metabolic processISSbiological_process
GO:0019530taurine metabolic processISSbiological_process
GO:0046449creatinine metabolic processISSbiological_process