Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HRH1_HUMAN
Description:histamine receptor H1 [Source:HGNC Symbol;Acc:5182]
Location:chr3 p25.3
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T142KYRTKtRASATCaM-KII_alphaphosphoELM
S398RLRSHsRQYVSBARK1(GRK2RegPhos
S275GSVLKsPSQTPHPRD; phosphoELM; SysPTM
Y321GSSRDyVAVNR7tm_1PhosphoSitePlus
S398RLRSHsRQYVSPKC_alphaphosphoELM
S396WKRLRsHSRQYPKG1RegPhos
T478ENFKKtFKRILPKC_alphaphosphoELM
T140YLKYRtKTRASCaMK2aRegPhos
S398RLRSHsRQYVSPKCa(PKC alphaRegPhos
Y401SHSRQyVSGLH7tm_1PhosphoSitePlus
S398RLRSHsRQYVSCaMK2aRegPhos
S398RLRSHsRQYVSCaM-KII_alphaphosphoELM
Y386NTGLDyIKFTW7tm_1PhosphoSitePlus
S398RLRSHsRQYVSPKA_groupphosphoELM; RegPhos
T478ENFKKtFKRILPKCa(PKC alphaRegPhos
S398RLRSHsRQYVSGRK-2phosphoELM
S380KLRSGsNTGLDHPRD; phosphoELM
T142KYRTKtRASATCaMK2aRegPhos
S396WKRLRsHSRQYPKC_alphaphosphoELM
S396WKRLRsHSRQYCaM-KII_alphaphosphoELM
S398RLRSHsRQYVSPKG1/cGK-IphosphoELM
T279KSPSQtPKEMK7tm_1PhosphoSitePlus
S380KLRSGsNTGLD7tm_1PhosphoSitePlus
S396WKRLRsHSRQYPKG1/cGK-IphosphoELM
S396WKRLRsHSRQYCaMK2aRegPhos
T140YLKYRtKTRASCaM-KII_alphaphosphoELM
T142KYRTKtRASAT7tm_1PhosphoSitePlus
S396WKRLRsHSRQYPKCa(PKC alphaRegPhos
T279KSPSQtPKEMKHPRD; phosphoELM
S396WKRLRsHSRQY7tm_1PhosphoSitePlus
T478ENFKKtFKRILPhosphoSitePlus
S275GSVLKsPSQTP7tm_1PhosphoSitePlus; SysPTM
S70YIVSLsVADLITM; 7tm_1PhosphoSitePlus
S398RLRSHsRQYVS7tm_1PhosphoSitePlus
S255KPGKEsPWEVLHPRD; SysPTM
T140YLKYRtKTRAS7tm_1PhosphoSitePlus
Y301EVDKLyCFPLD7tm_1PhosphoSitePlus
S255KPGKEsPWEVL7tm_1PhosphoSitePlus; SysPTM
S68NLYIVsLSVADTM; 7tm_1PhosphoSitePlus
S398RLRSHsRQYVSPKG1RegPhos

Dephosphorylation site
HRH1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380247R395LCOSMICHead and Neck Cancer21798893
ENSP00000380247D385ESjoblom2006, COSMICIntestines Cancer16959974
ENSP00000406705D385EHPIColorectal Cancer16959974
ENSP00000380247D385EHPIColorectal Cancer16959974
ENSP00000380247A23SCOSMICOvarian Cancer21720365
ENSP00000397028D385EHPIColorectal Cancer16959974

Differential expressed protein
HRH1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HRH1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HDC_HUMANHRH1_HUMANligand -> receptorHPMR
ARBK1_HUMANHRH1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANHRH1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032962positive regulation of inositol trisphosphate biosISSbiological_process
GO:0071420cellular response to histamineISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepTASbiological_process
GO:0004969histamine receptor activityISSmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0048016inositol phosphate-mediated signalingISSbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0005737cytoplasmIDAcellular_component