Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RLA2_HUMAN
Description:ribosomal protein, large, P2 [Source:HGNC Symbol;Acc:10377]
Location:chr11 p15.5
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y3___MRyVASYLPhosphoSitePlus
S74GAVAVsAAPGSRibosomal_60sPhosphoSitePlus
S17LGGNSsPSAKDHPRD; phosphoELM; RegPhos; SysPTM
Y7LAALHPRD
S105EESEEsDDDMGRibosomal_60sPhosphoSitePlus; SysPTM
S102EKKEEsEESDDBARK1(GRK2RegPhos; SysPTM
S102EKKEEsEESDDGRK-2phosphoELM; SysPTM
S86APAAGsAPAAARibosomal_60sPhosphoSitePlus
S64IGKLAsVPAGGHPRD; phosphoELM
S105EESEEsDDDMGphosphoELM; RegPhos; SysPTM
S6MRYVAsYLLAAPhosphoSitePlus
S105EESEEsDDDMGADRBK1HPRD; SysPTM
Y3ASYLHPRD
S79SAAPGsAAPAAHPRD; phosphoELM; SysPTM
S74GAVAVsAAPGSHPRD
S105EESEEsDDDMGGRK-2phosphoELM; SysPTM
S105EESEEsDDDMGBARK1RegPhos; SysPTM
S19GNSSPsAKDIKRibosomal_60sPhosphoSitePlus
S102EKKEEsEESDDADRBK1HPRD; SysPTM
S79SAAPGsAAPAARibosomal_60sPhosphoSitePlus; SysPTM
S6LLAAHPRD
S105EESEEsDDDMGBARK1(GRK2RegPhos; SysPTM
S86APAAGsAPAAAHPRD; phosphoELM
S17LGGNSsPSAKDRibosomal_60sPhosphoSitePlus; SysPTM
S102EKKEEsEESDDphosphoELM; RegPhos; SysPTM
S102EKKEEsEESDDBARK1RegPhos; SysPTM
S102EKKEEsEESDDRibosomal_60sPhosphoSitePlus; SysPTM
Y7RYVASyLLAALPhosphoSitePlus
S19GNSSPsAKDIKHPRD
S29KKILDsVGIEARibosomal_60sPhosphoSitePlus
S16ALGGNsSPSAKPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
RLA2_HUMAN do not have dephosphorylation site.

Mutation site
RLA2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000322419hepatitis B virusNormal vs. Cancercell lineUp1.819626621
ENSP00000322419Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineDown19795389
ENSP00000322419Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217
ENSP00000322419Breast CancerNormal vs. CancertissueUp20560667
ENSP00000322419acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1617655343
ENSP00000322419acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000322419Uterine CancerCancer vs. Cancercell lineUp17616526

Hyperphosphorylation site
RLA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRLA2_HUMANkinase -> substrateRegPhos
ARBK1_HUMANRLA2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03010Ribosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016032viral reproductionTASbiological_process
GO:0006414translational elongationTASbiological_process
GO:0006614SRP-dependent cotranslational protein targeting toTASbiological_process
GO:0019058viral infectious cycleTASbiological_process
GO:0022625cytosolic large ribosomal subunitIDAcellular_component
GO:0005840ribosomeIEAcellular_component
GO:0003723RNA bindingTASmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0006412translationNASbiological_process
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0003735structural constituent of ribosomeNASmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0006415translational terminationTASbiological_process
GO:0019083viral transcriptionTASbiological_process
GO:0006413translational initiationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0016070RNA metabolic processTASbiological_process


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