Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCG_HUMAN
Description:protein kinase C, gamma [Source:HGNC Symbol;Acc:9402]
Location:chr19 q13.42
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y521CGTPDyIAPEIPkinasePhosphoSitePlus
T511VFPGTtTRTFCHPRD; phosphoELM
T674DFQGFtYVNPDPkinase_CPhosphoSitePlus
T510NVFPGtTTRTFHPRD; phosphoELM
T514GTTTRtFCGTPHPRD; phosphoELM; SysPTM
T510NVFPGtTTRTFPkinasePhosphoSitePlus
T655AAPALtPPDRLHPRD; phosphoELM; SysPTM
T514GTTTRtFCGTPPkinasePhosphoSitePlus; SysPTM
T518RTFCGtPDYIAPkinasePhosphoSitePlus
Y529PEIIAyQPYGKPkinasePhosphoSitePlus
T512FPGTTtRTFCGHPRD; phosphoELM
Y195GLSDPyVKLKLC2PhosphoSitePlus
T655AAPALtPPDRLPkinase_CPhosphoSitePlus; SysPTM
Y195GLSDPyVKLKLphosphoELM
T511VFPGTtTRTFCPkinasePhosphoSitePlus
S320VRMGPsSSPIPPhosphoSitePlus
T518RTFCGtPDYIAHPRD; phosphoELM
T674DFQGFtYVNPDphosphoELM

Dephosphorylation site
KPCG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263431P524RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263431P343ADing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263431M317IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263431S109RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263431Y521NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263431D254NTCGAOvarian Cancer21720365, 18772890
ENSP00000263431R252HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263431D193NTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
KPCG_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T655Pkinase_CTRAAPALtPPDRLVLspinocerebellar ataxia type 1415964845PhosphoSitePlus
T514PkinaseFPGTTTRtFCGTPDYspinocerebellar ataxia type 1415964845PhosphoSitePlus
T674Pkinase_CQADFQGFtYVNPDFVspinocerebellar ataxia type 1415964845PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCG_HUMANVTNC_HUMANkinase -> substrateHPRD
KPCG_HUMANIRS1_HUMANkinase -> substrateHPRD
KPCG_HUMANIF4E_HUMANkinase -> substrateHPRD
KPCG_HUMANPA2G4_HUMANkinase -> substrateHPRD
KPCG_HUMANPEBP1_HUMANkinase -> substrateHPRD
KPCG_HUMANCASR_HUMANkinase -> substrateHPRD
KPCG_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCG_HUMANCYH2_HUMANkinase -> substrateHPRD
KPCG_HUMANCXA1_HUMANkinase -> substrateHPRD
KPCG_HUMANARBK1_HUMANkinase -> substrateHPRD
KPCG_HUMANDVL2_HUMANkinase -> substrateNetPath
KPCG_HUMANGSK3A_HUMANkinase -> substrateHPRD
KPCG_HUMANNEUG_HUMANkinase -> substrateHPRD
KPCG_HUMANNMDE2_HUMANkinase -> substrateHPRD
KPCG_HUMANHABP4_HUMANkinase -> substrateHPRD
KPCG_HUMANSTXB1_HUMANkinase -> substrateHPRD
KPCG_HUMANCD5_HUMANkinase -> substrateHPRD
KPCG_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCG_HUMANDAB2_HUMANkinase -> substrateHPRD
KPCG_HUMANOCLN_HUMANkinase -> substrateHPRD
KPCG_HUMANTOP2A_HUMANkinase -> substrateHPRD
KPCG_HUMANSDC2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa04730Long-term depression
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04725Cholinergic synapse
hsa05032Morphine addiction
hsa04666Fc gamma R-mediated phagocytosis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa05031Amphetamine addiction
hsa04540Gap junction
hsa04020Calcium signaling pathway
hsa04010MAPK signaling pathway
hsa05214Glioma
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04724Glutamatergic synapse
hsa04530Tight junction
hsa05200Pathways in cancer
hsa04960Aldosterone-regulated sodium reabsorption
hsa04150mTOR signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04370VEGF signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04012ErbB signaling pathway
hsa04726Serotonergic synapse
hsa04070Phosphatidylinositol signaling system
hsa05143African trypanosomiasis
hsa04972Pancreatic secretion
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05110Vibrio cholerae infection
hsa05223Non-small cell lung cancer
hsa05146Amoebiasis
hsa04720Long-term potentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004697protein kinase C activityTASmolecular_function
GO:0043278response to morphineIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0048265response to painIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0048265response to painISSbiological_process
GO:0004698calcium-dependent protein kinase C activityIEAmolecular_function
GO:0042177negative regulation of protein catabolic processIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0031397negative regulation of protein ubiquitinationIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007611learning or memoryIEAbiological_process
GO:0097060synaptic membraneIEAcellular_component
GO:0005886plasma membraneISScellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004697protein kinase C activityIEAmolecular_function
GO:0030425dendriteISScellular_component
GO:0060384innervationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0043278response to morphineISSbiological_process
GO:0005829cytosolISScellular_component
GO:0030168platelet activationTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0032425positive regulation of mismatch repairIDAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0007635chemosensory behaviorIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016310phosphorylationIDAbiological_process
GO:0030425dendriteIEAcellular_component


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