Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOP1_HUMAN
Description:topoisomerase (DNA) I [Source:HGNC Symbol;Acc:11986]
Location:chr20 q12
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S423ENIQGsIKYIMTopoisom_I_NPhosphoSitePlus
S57SEHKDsEKKHKPhosphoSitePlus; HPRD
Y268MLDHEyTTKEITopoisom_I_NPhosphoSitePlus
S2DHLHHPRD; SysPTM
S21FRLNDsHKHKDPhosphoSitePlus; HPRD
Y723TSKLNyLDPRIHanta_nucleocap; Topo_C_aPhosphoSitePlus
S111KENGFsSPPQIPhosphoSitePlus; HPRD
T303SKCDFtQMSQYTopoisom_I_NPhosphoSitePlus
Y268MLDHEyTTKEIAblphosphoELM
S432IMLNPsSRIKGHPRD
S2____MsGDHLHPhosphoSitePlus; SysPTM
S73KHKDGsSEKHKPhosphoSitePlus; HPRD
S394DAKVPsPPPGHTopoisom_I_NPhosphoSitePlus
Y268MLDHEyTTKEIABL1RegPhos
S74HKDGSsEKHKDPhosphoSitePlus
Y444KDWQKyETARRTopoisom_IPhosphoSitePlus
Y426QGSIKyIMLNPTopoisom_I_NPhosphoSitePlus
S686KKVVEsKKKAVHanta_nucleocapPhosphoSitePlus
S506TVGCCsLRVEHPhosphoSitePlus
S298IITNLsKCDFTHPRD
S112ENGFSsPPQIKPhosphoSitePlus; HPRD; phosphoELM
Y125PEDDGyFVPPKPhosphoSitePlus; HPRD
T295EKNIItNLSKCTopoisom_I_NPhosphoSitePlus
S10HLHNDsQIEADPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T649MMNLQtKIDAKTopoisom_I; Hanta_nucleocPhosphoSitePlus
Y426QGSIKyIMLNPHPRD
S298IITNLsKCDFTTopoisom_I_NPhosphoSitePlus

Dephosphorylation site
TOP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354522R449WCOSMICOvarian Cancer20826764
ENSP00000354522A96SCOSMICOvarian Cancer21720365
ENSP00000354522P560LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000354522D533GHPILeukemia1849260
ENSP00000354522M319TBIOMARTBreast Cancer21930507, 21930502
ENSP00000354522P560LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000354522N623SCOSMICBreast Cancer20668451
ENSP00000354522K326RHPI, COSMICBreast Cancer16959974
ENSP00000354522M370THPILeukemia7882333
ENSP00000354522T729AHPILung Cancer1332703 18772225
ENSP00000354522A96STCGAOvarian Cancer21720365, 18772890
ENSP00000354522N722SHPILeukemia7882333 18443285 11212241 9632354 8938793 7961822

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354522Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.520804217

Hyperphosphorylation site
TOP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTOP1_HUMANkinase -> substrateRegPhos
ABL1_HUMANTOP1_HUMANkinase -> substrateRegPhos
CEBPB_HUMANTOP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TOP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006338chromatin remodelingIBAbiological_process
GO:0005694chromosomeIEAcellular_component
GO:0040016embryonic cleavageIEAbiological_process
GO:0006265DNA topological changeIBAbiological_process
GO:0042493response to drugIEPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016310phosphorylationNASbiological_process
GO:0007059chromosome segregationIBAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006260DNA replicationIBAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0012501programmed cell deathNASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0000932cytoplasmic mRNA processing bodyIDAcellular_component
GO:0005654nucleoplasmIDAcellular_component
GO:0031298replication fork protection complexIBAcellular_component
GO:0006265DNA topological changeIEAbiological_process
GO:0043204perikaryonIEAcellular_component
GO:0003682chromatin bindingIDAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activiIEAmolecular_function
GO:0003917DNA topoisomerase type I activityIDAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000228nuclear chromosomeIDAcellular_component
GO:0003917DNA topoisomerase type I activityIEAmolecular_function