Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:YAP1_HUMAN
Description:Yes-associated protein 1 [Source:HGNC Symbol;Acc:16262]
Location:chr11 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S321SSPGMsQELRTHPRD; phosphoELM; RegPhos
S127HVRAHsSPASLPhosphoSitePlus; phosphoELM; RegPhos
S356GLSMSsYSVPRHPRD
S355SGLSMsSYSVPHPRD
S127HVRAHsSPASLPKB_groupphosphoELM
S238QRISQsAPVKQHPRD; phosphoELM; RegPhos; SysPTM
S164HLRQSsFEIPDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S103PPEPKsHSRQAPhosphoSitePlus; HPRD
S127HVRAHsSPASLAKT1HPRD; RegPhos
S432DTINQsTLPSQPhosphoSitePlus
S367QNPVSsPGMSQPhosphoSitePlus
S127HVRAHsSPASLAKT_groupRegPhos
S276QRISQsAPVKQPhosphoSitePlus
T145GTLTPtGVVSGPhosphoSitePlus; HPRD
T110SRQAStDAGTAPhosphoSitePlus; HPRD; RegPhos; SysPTM
T154SGPAAtPTAQHPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S138QLGAVsPGTLTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y357LSMSSySVPRTABL1HPRD
S109HSRQAsTDAGTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S260GVMGGsNSNQQHPRD; phosphoELM
S274MNQRIsQSAPVPhosphoSitePlus
S217VTAPTsPPVQQHPRD
T141AVSPGtLTPTGPhosphoSitePlus; HPRD; phosphoELM
S251PLAPQsPQGGVHPRD; phosphoELM; SysPTM
S128VRAHSsPASLQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S331TMTTNsSDPFLHPRD; phosphoELM
T114STDAGtAGALTPhosphoSitePlus; HPRD
S397HSRDEsTDSGLPhosphoSitePlus
S353TDSGLsMSSYSHPRD; phosphoELM
S236MNQRIsQSAPVHPRD; phosphoELM; SysPTM
T119TAGALtPQHVRPhosphoSitePlus; HPRD
S371SSPGMsQELRTPhosphoSitePlus
S358SMSSYsVPRTPHPRD
S94RKLPDsFFKPPPhosphoSitePlus
Y391LNSGTyHSRDEPhosphoSitePlus
S347HSRDEsTDSGLHPRD; phosphoELM; RegPhos
T390FLNSGtYHSRDPhosphoSitePlus
S105EPKSHsRQASTPhosphoSitePlus; HPRD
S340PSTANsPKCQEPhosphoSitePlus
S382MTTNSsDPFLNPhosphoSitePlus
S366TQNPVsSPGMSPhosphoSitePlus
Y407LSMSSySVPRTPhosphoSitePlus
T398SRDEStDSGLSPhosphoSitePlus
S163QHLRQsSFEIPPhosphoSitePlus; HPRD; phosphoELM
S289PLAPQsPQGGVPhosphoSitePlus
S149PTGVVsGPAATPhosphoSitePlus; HPRD; phosphoELM
S350DESTDsGLSMSHPRD
S61HVRGDsETDLEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T348SRDEStDSGLSHPRD; phosphoELM; RegPhos
S317QNPVSsPGMSQHPRD; phosphoELM; SysPTM
T156PAATPtAQHLRPhosphoSitePlus; HPRD; phosphoELM
S131HSSPAsLQLGAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T63RGDSEtDLEALPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T143SPGTLtPTGVVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
YAP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331023Q162RCOSMICLung Cancer20668451
ENSP00000331023M225ICOSMICCentral Nervous System Neoplasms21163964
ENSP00000282441G244ACOSMICHead and Neck Cancer21798893
ENSP00000331023L454ICOSMICOvarian Cancer21720365

Differential expressed protein
YAP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S127PQHVRAHsSPASLQLlung cancer21060948PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANYAP1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANYAP1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANYAP1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
YAP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0046622positive regulation of organ growthIEAbiological_process
GO:0060242contact inhibitionIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0072091regulation of stem cell proliferationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0035329hippo signaling cascadeIEAbiological_process
GO:0071480cellular response to gamma radiationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0003143embryonic heart tube morphogenesisIEAbiological_process
GO:0070064proline-rich region bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0010837regulation of keratinocyte proliferationIEAbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0001570vasculogenesisIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0048339paraxial mesoderm developmentIEAbiological_process
GO:0030903notochord developmentIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0030857negative regulation of epithelial cell differentiaIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0035329hippo signaling cascadeTASbiological_process
GO:0001076RNA polymerase II transcription factor binding traIEAmolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048368lateral mesoderm developmentIEAbiological_process