| UniProt/SwissProt ID: | WASF2_HUMAN |
| Description: | WAS protein family, member 2 [Source:HGNC Symbol;Acc:12733] |
| Location: | chr1 p36.11 |
| Node attribute: | PPI(target); substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S292 | AGPKRsSVVSP | PhosphoSitePlus; HPRD | |
| Y139 | NNLTPyRDDGK | PhosphoSitePlus | |
| S259 | SASSPsPSFSE | PhosphoSitePlus | |
| S497 | DEDDWsD____ | PhosphoSitePlus | |
| T129 | YNTCDtPPPLN | PhosphoSitePlus | |
| S293 | GPKRSsVVSPS | PhosphoSitePlus | |
| Y155 | YTDPSyFFDLW | PhosphoSitePlus | |
| S308 | APPLGsPPGPK | PhosphoSitePlus; HPRD | |
| S284 | DNQRGsGLAGP | PhosphoSitePlus | |
| Y150 | EALKFyTDPSY | PhosphoSitePlus | |
| S482 | IAVEYsDSEDD | PhosphoSitePlus; HPRD; RegPhos | |
| T346 | FGSPGtPPPPS | PhosphoSitePlus | |
| T80 | LQVKVtQLDPK | PhosphoSitePlus; HPRD | |
| S488 | DSEDDsSEFDE | PhosphoSitePlus; HPRD; RegPhos | |
| Y150 | EALKFyTDPSY | Abl | phosphoELM |
| S296 | RSSVVsPSHPP | PhosphoSitePlus | |
| S257 | SDSASsPSPSF | PhosphoSitePlus | |
| Y150 | EALKFyTDPSY | ABL1 | RegPhos |
| S298 | SVVSPsHPPPA | PhosphoSitePlus | |
| Y230 | PPTLVyQNGSI | PhosphoSitePlus | |
| S442 | RSDLLsAIRQG | HPRD | |
| S351 | TPPPPsPPSFP | PhosphoSitePlus | |
| S343 | PVGFGsPGTPP | PhosphoSitePlus | |
| S489 | SEDDSsEFDED | PhosphoSitePlus; HPRD; RegPhos | |
| T168 | KMLQDtKDIMK | PhosphoSitePlus | |
| S484 | VEYSDsEDDSS | PhosphoSitePlus; HPRD; RegPhos | |
| Dephosphorylation site |
| WASF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000396211 | P268A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000396211 | D279N | COSMIC | Skin Cancer | 21984974 | ENSP00000396211 | G233D | COSMIC | Melanoma |
| Differential expressed protein |
| WASF2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WASF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL1_HUMAN | WASF2_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | WASF2_HUMAN | kinase -> substrate | RegPhos |
| BAIP2_HUMAN | WASF2_HUMAN | other | KEGG |
| WASF2_HUMAN | ARPC5_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05132 | Salmonella infection |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa05131 | Shigellosis |
| hsa04520 | Adherens junction |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001726 | ruffle | IEA | cellular_component |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0030048 | actin filament-based movement | IEA | biological_process |
| GO:0030027 | lamellipodium | IDA | cellular_component |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | TAS | biological_process |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0005769 | early endosome | IEA | cellular_component |
| GO:0001667 | ameboidal cell migration | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030032 | lamellipodium assembly | IEA | biological_process |
| GO:0006928 | cellular component movement | IEA | biological_process |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0016601 | Rac protein signal transduction | IEA | biological_process |
| GO:0001525 | angiogenesis | IEA | biological_process |