Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WASF2_HUMAN
Description:WAS protein family, member 2 [Source:HGNC Symbol;Acc:12733]
Location:chr1 p36.11
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S292AGPKRsSVVSPPhosphoSitePlus; HPRD
Y139NNLTPyRDDGKPhosphoSitePlus
S259SASSPsPSFSEPhosphoSitePlus
S497DEDDWsD____PhosphoSitePlus
T129YNTCDtPPPLNPhosphoSitePlus
S293GPKRSsVVSPSPhosphoSitePlus
Y155YTDPSyFFDLWPhosphoSitePlus
S308APPLGsPPGPKPhosphoSitePlus; HPRD
S284DNQRGsGLAGPPhosphoSitePlus
Y150EALKFyTDPSYPhosphoSitePlus
S482IAVEYsDSEDDPhosphoSitePlus; HPRD; RegPhos
T346FGSPGtPPPPSPhosphoSitePlus
T80LQVKVtQLDPKPhosphoSitePlus; HPRD
S488DSEDDsSEFDEPhosphoSitePlus; HPRD; RegPhos
Y150EALKFyTDPSYAblphosphoELM
S296RSSVVsPSHPPPhosphoSitePlus
S257SDSASsPSPSFPhosphoSitePlus
Y150EALKFyTDPSYABL1RegPhos
S298SVVSPsHPPPAPhosphoSitePlus
Y230PPTLVyQNGSIPhosphoSitePlus
S442RSDLLsAIRQGHPRD
S351TPPPPsPPSFPPhosphoSitePlus
S343PVGFGsPGTPPPhosphoSitePlus
S489SEDDSsEFDEDPhosphoSitePlus; HPRD; RegPhos
T168KMLQDtKDIMKPhosphoSitePlus
S484VEYSDsEDDSSPhosphoSitePlus; HPRD; RegPhos

Dephosphorylation site
WASF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000396211P268ACOSMICOvarian Cancer21720365
ENSP00000396211D279NCOSMICSkin Cancer21984974
ENSP00000396211G233DCOSMICMelanoma

Differential expressed protein
WASF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WASF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANWASF2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANWASF2_HUMANkinase -> substrateRegPhos
BAIP2_HUMANWASF2_HUMANotherKEGG
WASF2_HUMANARPC5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05132Salmonella infection
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa04520Adherens junction
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001726ruffleIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0030048actin filament-based movementIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0015629actin cytoskeletonTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005622intracellularIDAcellular_component
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005769early endosomeIEAcellular_component
GO:0001667ameboidal cell migrationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0006928cellular component movementIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0016601Rac protein signal transductionIEAbiological_process
GO:0001525angiogenesisIEAbiological_process


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