| UniProt/SwissProt ID: | GLYAT_HUMAN |
| Description: | glycine-N-acyltransferase [Source:HGNC Symbol;Acc:13734] |
| Location: | chr11 q12.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T278 | QKMSYtLQHVP | Gly_acyl_tr_C | PhosphoSitePlus |
| Y248 | VTYVIySHAQK | Gly_acyl_tr_C | PhosphoSitePlus |
| Dephosphorylation site |
| GLYAT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000431688 | H264D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000340200 | H264D | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000340200 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | |
| Hyperphosphorylation site |
| GLYAT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL1_HUMAN | GLYAT_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | GLYAT_HUMAN | kinase -> substrate | RegPhos |
| ABL2_HUMAN | GLYAT_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| M4K5_HUMAN | GLYAT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00360 | Phenylalanine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016746 | transferase activity, transferring acyl groups | TAS | molecular_function |
| GO:0006544 | glycine metabolic process | ISS | biological_process |
| GO:0006805 | xenobiotic metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0009636 | response to toxin | IEA | biological_process |
| GO:0032787 | monocarboxylic acid metabolic process | ISS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0006637 | acyl-CoA metabolic process | TAS | biological_process |
| GO:0047961 | glycine N-acyltransferase activity | IEA | molecular_function |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0047962 | glycine N-benzoyltransferase activity | ISS | molecular_function |
| GO:0005739 | mitochondrion | ISS | cellular_component |