Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ROBO1_HUMAN
Description:roundabout, axon guidance receptor, homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:10249]
Location:chr3 p12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1396RHFHAsQCPRPHPRD
S1567PSSSSsMSSRGHPRD
Y1075VAPVQyNIVEQHPRD
S75IVEHPsDLIVSI-setPhosphoSitePlus
T520AKLGDtGRYTCI-setPhosphoSitePlus
S1565RDPSSsSSMSSHPRD
S1297RRQPVsPPPPPPhosphoSitePlus; HPRD; phosphoELM
T944PSFTFtPTVTYHPRD; phosphoELM; SysPTM
S901IRKVPsFTFTPHPRD
S1453PPAIKsPTAQSHPRD
Y1114VAPVQyNIVEQPhosphoSitePlus; HPRD
S1604RDPSSsSSMSSHPRD
Y949TPTVTyQRGGEPhosphoSitePlus
S855VEVAAsTGAGSfn3PhosphoSitePlus
Y1073GQPTPyATTQLABL1RegPhos
T1240DERGPtPPVRGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S80SDLIVsKGEPAI-setPhosphoSitePlus
Y893GLTSTyAGIRKHPRD
Y1587EDILPyCRPTFPhosphoSitePlus
S1492PPAIKsPTAQSHPRD; phosphoELM
Y1272SPPHTyGYISGHPRD
Y1311SPPHTyGYISGHPRD; phosphoELM
Y1038PESTVyGDVDLABL1RegPhos
S1603PRDPSsSSSMSPhosphoSitePlus
S1606PSSSSsMSSRGHPRD
Y932GLTSTyAGIRKPhosphoSitePlus; HPRD
S940IRKVPsFTFTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y1073GQPTPyATTQLPhosphoSitePlus
T905PSFTFtPTVTYHPRD
T42GNDHGtPIPTSPhosphoSitePlus
S1442CPRPTsPVSTDPhosphoSitePlus
S1258RRQPVsPPPPPHPRD
Y1126KLNKDyRANDTPhosphoSitePlus; HPRD
T1441QCPRPtSPVSTPhosphoSitePlus
T1455AIKSPtAQSKTHPRD
S251VGEREsEVAELI-setPhosphoSitePlus
S1306PPRPIsPPHTYHPRD; phosphoELM
Y1038PESTVyGDVDLPhosphoSitePlus
Y1413AAAAEyAGLKVPhosphoSitePlus
T1494AIKSPtAQSKTHPRD; phosphoELM
T1201DERGPtPPVRGHPRD
T942KVPSFtFTPTVHPRD; phosphoELM; SysPTM
Y1114VAPVQyNIVEQABL1RegPhos
S1016MKTFNsPNLKDHPRD
S1055MKTFNsPNLKDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S305GELPKsRYEIRI-setPhosphoSitePlus
S1267PPRPIsPPHTYHPRD
Y1087KLNKDyRANDTHPRD
S1528DRKGSsYKGREPhosphoSitePlus
T321KIRKVtAGDMGI-setPhosphoSitePlus
S1435RHFHAsQCPRPHPRD; SysPTM
T903KVPSFtFTPTVHPRD

Dephosphorylation site
ROBO1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000420637H682RBIOMARTBreast Cancer21930507, 21930502
ENSP00000420321E1049DCOSMICHead and Neck Cancer21798893
ENSP00000420321P1550SCOSMICHead and Neck Cancer21798893
ENSP00000420321E1533DHPIBreast Cancer12082532
ENSP00000420637S1550*BIOMARTBreast Cancer21930507, 21930502
ENSP00000420321S1609TCOSMICOvarian Cancer21720365
ENSP00000420321H718RBIOMARTBreast Cancer21930507, 21930502
ENSP00000420321S1055NHPIBreast Cancer12082532
ENSP00000420321S1595*BIOMARTBreast Cancer21930507, 21930502
ENSP00000420321A933VCOSMICLymphoma21642962

Differential expressed protein
ROBO1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ROBO1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANROBO1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANROBO1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007411axon guidanceTASbiological_process
GO:0021836chemorepulsion involved in postnatal olfactory bulIDAbiological_process
GO:0042802identical protein bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007156homophilic cell adhesionIDAbiological_process
GO:0060763mammary duct terminal end bud growthIEAbiological_process
GO:0050772positive regulation of axonogenesisIDAbiological_process
GO:0016199axon midline choice point recognitionISSbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070100negative regulation of chemokine-mediated signalinIMPbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0030275LRR domain bindingIPImolecular_function
GO:0050925negative regulation of negative chemotaxisIDAbiological_process
GO:0002042cell migration involved in sprouting angiogenesisIMPbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0035385Roundabout signaling pathwayIMPbiological_process
GO:0008046axon guidance receptor activityTASmolecular_function
GO:0030673axolemmaIEAcellular_component
GO:0006919activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0033600negative regulation of mammary gland epithelial ceIMPbiological_process
GO:0009986cell surfaceIDAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23