| UniProt/SwissProt ID: | ROBO1_HUMAN |
| Description: | roundabout, axon guidance receptor, homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:10249] |
| Location: | chr3 p12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1396 | RHFHAsQCPRP | HPRD | |
| S1567 | PSSSSsMSSRG | HPRD | |
| Y1075 | VAPVQyNIVEQ | HPRD | |
| S75 | IVEHPsDLIVS | I-set | PhosphoSitePlus |
| T520 | AKLGDtGRYTC | I-set | PhosphoSitePlus |
| S1565 | RDPSSsSSMSS | HPRD | |
| S1297 | RRQPVsPPPPP | PhosphoSitePlus; HPRD; phosphoELM | |
| T944 | PSFTFtPTVTY | HPRD; phosphoELM; SysPTM | |
| S901 | IRKVPsFTFTP | HPRD | |
| S1453 | PPAIKsPTAQS | HPRD | |
| Y1114 | VAPVQyNIVEQ | PhosphoSitePlus; HPRD | |
| S1604 | RDPSSsSSMSS | HPRD | |
| Y949 | TPTVTyQRGGE | PhosphoSitePlus | |
| S855 | VEVAAsTGAGS | fn3 | PhosphoSitePlus |
| Y1073 | GQPTPyATTQL | ABL1 | RegPhos |
| T1240 | DERGPtPPVRG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S80 | SDLIVsKGEPA | I-set | PhosphoSitePlus |
| Y893 | GLTSTyAGIRK | HPRD | |
| Y1587 | EDILPyCRPTF | PhosphoSitePlus | |
| S1492 | PPAIKsPTAQS | HPRD; phosphoELM | |
| Y1272 | SPPHTyGYISG | HPRD | |
| Y1311 | SPPHTyGYISG | HPRD; phosphoELM | |
| Y1038 | PESTVyGDVDL | ABL1 | RegPhos |
| S1603 | PRDPSsSSSMS | PhosphoSitePlus | |
| S1606 | PSSSSsMSSRG | HPRD | |
| Y932 | GLTSTyAGIRK | PhosphoSitePlus; HPRD | |
| S940 | IRKVPsFTFTP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y1073 | GQPTPyATTQL | PhosphoSitePlus | |
| T905 | PSFTFtPTVTY | HPRD | |
| T42 | GNDHGtPIPTS | PhosphoSitePlus | |
| S1442 | CPRPTsPVSTD | PhosphoSitePlus | |
| S1258 | RRQPVsPPPPP | HPRD | |
| Y1126 | KLNKDyRANDT | PhosphoSitePlus; HPRD | |
| T1441 | QCPRPtSPVST | PhosphoSitePlus | |
| T1455 | AIKSPtAQSKT | HPRD | |
| S251 | VGEREsEVAEL | I-set | PhosphoSitePlus |
| S1306 | PPRPIsPPHTY | HPRD; phosphoELM | |
| Y1038 | PESTVyGDVDL | PhosphoSitePlus | |
| Y1413 | AAAAEyAGLKV | PhosphoSitePlus | |
| T1494 | AIKSPtAQSKT | HPRD; phosphoELM | |
| T1201 | DERGPtPPVRG | HPRD | |
| T942 | KVPSFtFTPTV | HPRD; phosphoELM; SysPTM | |
| Y1114 | VAPVQyNIVEQ | ABL1 | RegPhos |
| S1016 | MKTFNsPNLKD | HPRD | |
| S1055 | MKTFNsPNLKD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S305 | GELPKsRYEIR | I-set | PhosphoSitePlus |
| S1267 | PPRPIsPPHTY | HPRD | |
| Y1087 | KLNKDyRANDT | HPRD | |
| S1528 | DRKGSsYKGRE | PhosphoSitePlus | |
| T321 | KIRKVtAGDMG | I-set | PhosphoSitePlus |
| S1435 | RHFHAsQCPRP | HPRD; SysPTM | |
| T903 | KVPSFtFTPTV | HPRD | |
| Dephosphorylation site |
| ROBO1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000420637 | H682R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420321 | E1049D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000420321 | P1550S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000420321 | E1533D | HPI | Breast Cancer | 12082532 | ENSP00000420637 | S1550* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420321 | S1609T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000420321 | H718R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420321 | S1055N | HPI | Breast Cancer | 12082532 | ENSP00000420321 | S1595* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000420321 | A933V | COSMIC | Lymphoma | 21642962 |
| Differential expressed protein |
| ROBO1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ROBO1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL1_HUMAN | ROBO1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | ROBO1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0021836 | chemorepulsion involved in postnatal olfactory bul | IDA | biological_process |
| GO:0042802 | identical protein binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007156 | homophilic cell adhesion | IDA | biological_process |
| GO:0060763 | mammary duct terminal end bud growth | IEA | biological_process |
| GO:0050772 | positive regulation of axonogenesis | IDA | biological_process |
| GO:0016199 | axon midline choice point recognition | ISS | biological_process |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0070100 | negative regulation of chemokine-mediated signalin | IMP | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0030275 | LRR domain binding | IPI | molecular_function |
| GO:0050925 | negative regulation of negative chemotaxis | IDA | biological_process |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IMP | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0035385 | Roundabout signaling pathway | IMP | biological_process |
| GO:0008046 | axon guidance receptor activity | TAS | molecular_function |
| GO:0030673 | axolemma | IEA | cellular_component |
| GO:0006919 | activation of cysteine-type endopeptidase activity | IMP | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0033600 | negative regulation of mammary gland epithelial ce | IMP | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |