Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRKL_HUMAN
Description:v-crk sarcoma virus CT10 oncogene homolog (avian)-like [Source:HGNC Symbol;Acc:2363]
Location:chr22 q11.21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y251RVPCAyDKTALHPRD; RegPhos
S42LVRDSsTCPGDSH2PhosphoSitePlus
Y132YVRTLyDFPGNHPRD; RegPhos; SysPTM
S232ITPLPsTQNGPPhosphoSitePlus
S42LVRDSsTCPGDHPRD
Y132YVRTLyDFPGNSH3_1PhosphoSitePlus; SysPTM
Y198RNSNSyGIPEPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T254CAYDKtALALESH3_2PhosphoSitePlus
T130LEYVRtLYDFPSH3_1PhosphoSitePlus
T212YAQPQtTTPLPPhosphoSitePlus; HPRD; phosphoELM
T43VRDSStCPGDYSH2PhosphoSitePlus
T96HYLDTtTLIEPPhosphoSitePlus
Y207EPAHAyAQPQTPhosphoSitePlus; HPRD; RegPhos
S222PAVSGsPGAAIPhosphoSitePlus; HPRD
Y92FYKIHyLDTTTPhosphoSitePlus
T95IHYLDtTTLIEPhosphoSitePlus
Y207EPAHAyAQPQTABL1RegPhos
S41FLVRDsSTCPGHPRD
T43VRDSStCPGDYHPRD
T213AQPQTtTPLPAPhosphoSitePlus
Y251RVPCAyDKTALSH3_2PhosphoSitePlus
S114PMGSVsAPNLPPhosphoSitePlus
T214QPQTTtPLPAVPhosphoSitePlus
T228PGAAItPLPSTPhosphoSitePlus
S195HGNRNsNSYGIPhosphoSitePlus; HPRD
S107APRYPsPPMGSPhosphoSitePlus; HPRD; RegPhos
Y207EPAHAyAQPQTAblphosphoELM
S220PLPAVsGSPGAPhosphoSitePlus
S184EKLVRsSPHGKPhosphoSitePlus; HPRD
Y48TCPGDyVLSVSSH2PhosphoSitePlus
S197NRNSNsYGIPEPhosphoSitePlus; HPRD; phosphoELM
Y127EDNLEyVRTLYPhosphoSitePlus

Dephosphorylation site
CRKL_HUMAN do not have dephosphorylation site.

Mutation site
CRKL_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000396646Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.4615169874

Hyperphosphorylation site
CRKL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANCRKL_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCRKL_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04062Chemokine signaling pathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa04510Focal adhesion
hsa04010MAPK signaling pathway
hsa05211Renal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048538thymus developmentIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0007254JNK cascadeTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035556intracellular signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060017parathyroid gland developmentIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function