Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD1_HUMAN
Description:SMAD family member 1 [Source:HGNC Symbol;Acc:6767]
Location:chr4 q31.21
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S195SSYPNsPGSSSErk2(MAPK1RegPhos
Y146PRHSEyNPQHSDUF605PhosphoSitePlus
S463HNPISsVSRegPhos
S78GRLQVsHRKGLMH1; DUF605PhosphoSitePlus
S206STYPHsPTSSDErk2RegPhos
S195SSYPNsPGSSSErk2RegPhos
S463HNPISsBMPR1BphosphoELM
S462PHNPIsSACVR1HPRD
S132YKRVEsPVLPPDUF605PhosphoSitePlus
S462PHNPIsSVS__PhosphoSitePlus
S463HNPISsVSBMPR1BRegPhos
S462PHNPIsSVSALK2RegPhos
S462PHNPIsSVSTGFbR1RegPhos
S463HNPISsTGFBR1HPRD
S195SSYPNsPGSSSDUF605PhosphoSitePlus
S465PISSVsRegPhos
T202GSSSStYPHSPDUF605PhosphoSitePlus
S214SSDPGsPFQMPErk2RegPhos
S462PHNPIsSVSBMPR1BRegPhos
T10SLFSFtSPAVKHPRD
S465PISSTGFBR1HPRD
S206STYPHsPTSSDMAPK1HPRD; phosphoELM
S463HNPISsVS___PhosphoSitePlus
S214SSDPGsPFQMPMAPK1HPRD; phosphoELM
S462PHNPIsSBMPR1BphosphoELM
S463HNPISsVSTGFbR1RegPhos
S465PISSVsALK2RegPhos
S465PISSHPRD; phosphoELM
S206STYPHsPTSSDErk2(MAPK1RegPhos
S214SSDPGsPFQMPDUF605PhosphoSitePlus
S187HPFPHsPNSSYMAPK1phosphoELM
S465PISSVsBMPR1BRegPhos
S462PHNPIsSTGFBR1HPRD
S462PHNPIsSphosphoELM
S206STYPHsPTSSDDUF605PhosphoSitePlus
S187HPFPHsPNSSYErk2(MAPK1RegPhos
S465PISSVsTGFbR1RegPhos
S463HNPISsHPRD; phosphoELM
S465PISSBMPR1BphosphoELM
S239MTQDGsQPMDTDUF605PhosphoSitePlus
S465PISSACVR1HPRD
S463HNPISsVSALK2RegPhos
T322VNRNStIENTRMH2PhosphoSitePlus
Y88LPHVIyCRVWRMH1; DUF605PhosphoSitePlus
S463HNPISsACVR1HPRD
S195SSYPNsPGSSSMAPK1HPRD; phosphoELM
S465PISSVs_____PhosphoSitePlus
S187HPFPHsPNSSYDUF605PhosphoSitePlus
S214SSDPGsPFQMPErk2(MAPK1RegPhos

Dephosphorylation site
SMAD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000426568Y127CCOSMICHead and Neck Cancer21798893
ENSP00000377652Y127CCOSMICHead and Neck Cancer21798893
ENSP00000305769Y127CCOSMICHead and Neck Cancer21798893
ENSP00000305769W420CTCGAOvarian Cancer21720365, 18772890
ENSP00000426568W420CTCGAOvarian Cancer21720365, 18772890
ENSP00000377652W420CTCGAOvarian Cancer21720365, 18772890
ENSP00000305769W420CCOSMICOvarian Cancer21720365
ENSP00000305769N180HBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000377652W420CCOSMICOvarian Cancer21720365
ENSP00000426568W420CCOSMICOvarian Cancer21720365

Differential expressed protein
SMAD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMAD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ACVR1_HUMANSMAD1_HUMANkinase -> substrateHPRD
TGFR1_HUMANSMAD1_HUMANkinase -> substrateHPRD
BMR1A_HUMANSMAD1_HUMANkinase -> substrateKEGG
BMR1B_HUMANSMAD1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANSMAD1_HUMANkinase -> substrateRegPhos
MK01_HUMANSMAD1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
SMAD6_HUMANSMAD1_HUMANotherKEGG
SMAD1_HUMANSMAD4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070410co-SMAD bindingIPImolecular_function
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042493response to drugIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0009880embryonic pattern specificationISSbiological_process
GO:0060348bone developmentIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:1901522positive regulation of transcription from RNA polyISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0061036positive regulation of cartilage developmentIEAbiological_process
GO:0005057receptor signaling protein activityNASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0050775positive regulation of dendrite morphogenesisIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process
GO:0071773cellular response to BMP stimulusISSbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0051216cartilage developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0030509BMP signaling pathwayISSbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0070411I-SMAD bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0005622intracellularNAScellular_component
GO:0001710mesodermal cell fate commitmentIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0030618transforming growth factor beta receptor, pathway-TASmolecular_function
GO:0010243response to organic nitrogenIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusTAScellular_component
GO:0042060wound healingIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0030901midbrain developmentIEAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005637nuclear inner membraneIDAcellular_component
GO:0007276gamete generationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0002051osteoblast fate commitmentIEAbiological_process
GO:0060038cardiac muscle cell proliferationIEAbiological_process
GO:0031053primary miRNA processingTASbiological_process
GO:0042592homeostatic processIEAbiological_process