| UniProt/SwissProt ID: | HASP_HUMAN |
| Description: | germ cell associated 2 (haspin) [Source:HGNC Symbol;Acc:19682] |
| Location: | chr17 p13.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T112 | PSLTVtPRRLG | PhosphoSitePlus | |
| S108 | LRARPsLTVTP | PhosphoSitePlus | |
| T191 | VISIGtSACLV | PhosphoSitePlus | |
| S93 | PKDRPsLTVTP | PhosphoSitePlus; HPRD; phosphoELM | |
| S216 | SLDRAsLPCSQ | PhosphoSitePlus; HPRD | |
| T289 | PGLSStGKRRA | PhosphoSitePlus; HPRD | |
| S220 | ASLPCsQEEAT | PhosphoSitePlus; HPRD; phosphoELM | |
| S58 | SIGDPsQSDDP | PhosphoSitePlus | |
| S147 | DSGRLsPDLSV | PhosphoSitePlus; HPRD; phosphoELM | |
| S288 | GPGLSsTGKRR | PhosphoSitePlus; HPRD | |
| T373 | PTQDLtPLQNV | PhosphoSitePlus | |
| T253 | LMNSGtPEDSE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T97 | PSLTVtPKRWK | PhosphoSitePlus; HPRD; phosphoELM | |
| S287 | EGPGLsSTGKR | PhosphoSitePlus; HPRD | |
| S340 | RSSRKsKHQEA | PhosphoSitePlus | |
| T128 | PQKCStPCGPL | PhosphoSitePlus | |
| S143 | FPSRDsGRLSP | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| HASP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000325290 | D365H | BIOMART | Gastric Cancer | 21930507, 21930502 |
| Differential expressed protein |
| HASP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HASP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HASP_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | LZTS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | PLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HASP_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005819 | spindle | IDA | cellular_component |
| GO:0090231 | regulation of spindle checkpoint | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0031965 | nuclear membrane | IDA | cellular_component |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:2000751 | histone H3-T3 phosphorylation involved in chromoso | IMP | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0005694 | chromosome | IEA | cellular_component |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0007064 | mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0071459 | protein localization to chromosome, centromeric re | IMP | biological_process |
| GO:0072354 | histone kinase activity (H3-T3 specific) | IMP | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |