| UniProt/SwissProt ID: | ALK_HUMAN |
| Description: | anaplastic lymphoma receptor tyrosine kinase [Source:HGNC Symbol;Acc:427] |
| Location: | chr2 p23.1 |
| Node attribute: | kinase; receptor; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S319 | EMPRGsFLLLN | MAM | PhosphoSitePlus |
| T1597 | PLEAAtAPGAG | PhosphoSitePlus | |
| Y1586 | NVNYGyQQQGL | PhosphoSitePlus | |
| Y1359 | CPGPVyRIMTQ | Pkinase_Tyr | PhosphoSitePlus |
| Y46 | REPLSySRLQR | PhosphoSitePlus | |
| T1607 | GHYEDtILKSK | PhosphoSitePlus | |
| T1087 | KLRTStIMTDY | PhosphoSitePlus | |
| Y1283 | YRASYyRKGGC | Pkinase_Tyr | PhosphoSitePlus |
| Y1078 | LQSPEyKLSKL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y1359 | CPGPVyRIMTQ | HPRD; phosphoELM | |
| S326 | LLLNTsADSKH | MAM | PhosphoSitePlus |
| Y1282 | IYRASyYRKGG | ALK | HPRD; phosphoELM; RegPhos |
| Y1283 | YRASYyRKGGC | ALK | HPRD; phosphoELM; RegPhos |
| S329 | NTSADsKHTIL | MAM | PhosphoSitePlus |
| T1090 | TSTIMtDYNPN | PhosphoSitePlus | |
| S312 | PGAERsKEMPR | MAM | PhosphoSitePlus |
| Y1131 | AFGEVyEGQVS | phosphoELM; RegPhos | |
| T1512 | YGSWFtEKPTK | PhosphoSitePlus | |
| S211 | AAIRAsQPRLL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y1283 | YRASYyRKGGC | phosphoELM | |
| Y1604 | PGAGHyEDTIL | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y1507 | LWNPTyGSWFT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y1282 | IYRASyYRKGG | phosphoELM | |
| T1506 | SLWNPtYGSWF | PhosphoSitePlus | |
| S47 | EPLSYsRLQRK | PhosphoSitePlus; HPRD | |
| Y1278 | MARDIyRASYY | ALK | RegPhos |
| S1509 | NPTYGsWFTEK | PhosphoSitePlus | |
| Y1096 | DYNPNyCFAGK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y1278 | MARDIyRASYY | HPRD; phosphoELM; RegPhos | |
| Y1278 | MARDIyRASYY | Pkinase_Tyr | PhosphoSitePlus |
| Y1092 | TIMTDyNPNYC | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S62 | DFVVPsLFRVY | PhosphoSitePlus | |
| Y1131 | AFGEVyEGQVS | Pkinase_Tyr | PhosphoSitePlus |
| Y1584 | CGNVNyGYQQQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y1282 | IYRASyYRKGG | Pkinase_Tyr | PhosphoSitePlus |
| Y1604 | PGAGHyEDTIL | ALK | HPRD; RegPhos |
| Y1282 | IYRASyYRKGG | autocatalysis | RegPhos |
| Y1401 | ALPIEyGPLVE | PhosphoSitePlus | |
| S1075 | QMELQsPEYKL | PhosphoSitePlus | |
| Dephosphorylation site |
| ALK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000373700 | A877S | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000373700 | S631I | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000373700 | P542R | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000373700 | I1171N | HPI | Neoplasms by Histologic Type | 18724359 21838707 | ENSP00000373700 | I1250T | HPI | Neoplasms by Histologic Type | 18724359 21804922 | ENSP00000373700 | D1091N | HPI | Neoplasms by Histologic Type | 18724359 | ENSP00000373700 | F1174V | HPI | Neoplasms by Histologic Type | 18923523 | ENSP00000373700 | R1192P | HPI | Neoplasms by Histologic Type | 18724359 18923523 22071890 21838707 | ENSP00000373700 | R1275Q | HPI | Neoplasms by Histologic Type | 18724359 18923523 18923525 22192458 22085494 22072639 21940108 21945349 21838707 21242967 | ENSP00000373700 | T1151M | HPI | Neoplasms by Histologic Type | 18923525 | ENSP00000373700 | R1192P | OMIM | Neoplasms by Histologic Type | 18724359 18923523 | ENSP00000373700 | V1135E | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000373700 | E1419K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000373700 | D832H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000373700 | G1128A | OMIM | Neoplasms by Histologic Type | 18724359 | ENSP00000373700 | P496L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000373700 | A1234T | HPI | Neoplasms by Histologic Type | 18923525 | ENSP00000373700 | R1275Q | OMIM | Neoplasms by Histologic Type | 18724359 18923523 18923525 18923524 | ENSP00000373700 | R401* | Greenman2007 | Ovarian Cancer | 17344846, 18428421 | ENSP00000373700 | Y1278S | HPI | Neoplasms by Histologic Type | 18923523 | ENSP00000373700 | M1166R | HPI | Neoplasms by Histologic Type | 18724359 | ENSP00000373700 | G1128A | HPI | Neoplasms by Histologic Type | 18724359 21838707 | ENSP00000373700 | T1151M | OMIM | Neoplasms by Histologic Type | 18923525 | ENSP00000373700 | F1245V | HPI | Neoplasms by Histologic Type | 18724359 22085494 | ENSP00000373700 | L560F | Greenman2007, HPI | Breast Cancer | 15908952, 17344846, 18428421 |
| Differential expressed protein |
| ALK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ALK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK_HUMAN | ALK_HUMAN | ligand -> receptor | HPMR |
| ZAGL2_HUMAN | ALK_HUMAN | kinase -> substrate | RegPhos |
| ALK_HUMAN | ALK_HUMAN | kinase -> substrate | RegPhos |
| PLK1_HUMAN | ALK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ALK_HUMAN | NIPA_HUMAN | kinase -> substrate | RegPhos |
| ALK_HUMAN | STAT3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| ALK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0000187 | activation of MAPK activity | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0038061 | NIK/NF-kappaB cascade | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | TAS | biological_process |
| GO:0004714 | transmembrane receptor protein tyrosine kinase act | TAS | molecular_function |
| GO:0046777 | protein autophosphorylation | TAS | biological_process |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0004704 | NF-kappaB-inducing kinase activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0016310 | phosphorylation | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0048666 | neuron development | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |