Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PIN1_HUMAN
Description:peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:8988]
Location:chr19 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S114QFSDCsSAKARHPRD
S72SRRPSsWRQEKRotamasePhosphoSitePlus
Y23SSGRVyYFNHIMBD; WWPhosphoSitePlus
S108FESLAsQFSDCHPRD; phosphoELM; RegPhos
S43SGNSSsGGKNGHPRD
S65LLVKHsQSRRPPLK1phosphoELM; RegPhos
S105EEDFEsLASQFRotamasePhosphoSitePlus
S138PFEDAsFALRTRotamasePhosphoSitePlus
S65LLVKHsQSRRPRotamasePhosphoSitePlus
S38QWERPsGNSSSMBDPhosphoSitePlus
S71QSRRPsSWRQERotamasePhosphoSitePlus
S16WEKRMsRSSGRMBD; WWPhosphoSitePlus
S16WEKRMsRSSGRPKA_groupphosphoELM; RegPhos
S108FESLAsQFSDCRotamasePhosphoSitePlus

Dephosphorylation site
PIN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000247970P149SCOSMICMelanoma21499247
ENSP00000247970S108*COSMICSkin Cancer21984974
ENSP00000247970Q33KCOSMICSkin Cancer21984974

Differential expressed protein
PIN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S138RotamaseQKPFEDAsFALRTGEbreast cancer22566623PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPIN1_HUMANkinase -> substrateRegPhos
PLK1_HUMANPIN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04622RIG-I-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032794GTPase activating protein bindingIPImolecular_function
GO:0001934positive regulation of protein phosphorylationIGIbiological_process
GO:0000413protein peptidyl-prolyl isomerizationIDAbiological_process
GO:0016853isomerase activityIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0006457protein foldingIEAbiological_process
GO:0030512negative regulation of transforming growth factor IDAbiological_process
GO:0060393regulation of pathway-restricted SMAD protein phosIDAbiological_process
GO:0032321positive regulation of Rho GTPase activityIMPbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0030496midbodyIDAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:2000146negative regulation of cell motilityIDAbiological_process
GO:0051443positive regulation of ubiquitin-protein ligase acIDAbiological_process
GO:0007088regulation of mitosisTASbiological_process
GO:0050815phosphoserine bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0003755peptidyl-prolyl cis-trans isomerase activityIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0032465regulation of cytokinesisIGIbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0050816phosphothreonine bindingIDAmolecular_function
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0031434mitogen-activated protein kinase kinase bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0032465regulation of cytokinesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23