Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BRCA2_HUMAN
Description:breast cancer 2, early onset [Source:HGNC Symbol;Acc:1101]
Location:chr13 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T207PTLSStVLIVRPhosphoSitePlus
T1282NHNDKtVSEKNPhosphoSitePlus
S3239MAKRKsVSTPVPhosphoSitePlus
T3242RKSVStPVSAQPhosphoSitePlus
S193VDPDMsWSSSLPhosphoSitePlus
S973GQDLKsDISLNPhosphoSitePlus
S519ETFNAsFSGHMPhosphoSitePlus
S1943GLEKVsKISPCPhosphoSitePlus
T2968SRDVTtVWKLRPhosphoSitePlus
T203LATPPtLSSTVPhosphoSitePlus
Y3009KRYRIyHLATSPhosphoSitePlus
T167GSLFHtPKFVKPhosphoSitePlus
S1926FADIQsEEILQPhosphoSitePlus
S805GNNYEsDVELTPhosphoSitePlus
S755DTDFQsQKSLLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S511FRIREsPKETFPhosphoSitePlus
S547IHTVCsQKEDSPhosphoSitePlus
Y1480MDILSyEETDIPhosphoSitePlus
T3199PTKDCtSGPYTPhosphoSitePlus
S239SNHDEsLKKNDPLK1HPRD; RegPhos
S205TPPTLsSTVLIPhosphoSitePlus
S76YNQLAsTPIIFPhosphoSitePlus
T3306PRSCGtKYETPPhosphoSitePlus
S384GSDKIsKEVVPPhosphoSitePlus; HPRD
T680TCSNNtVISQDPhosphoSitePlus
S3397KEQESsQASTEPhosphoSitePlus
Y1135FRKPSyILQKSPhosphoSitePlus
S3291ICTFVsPAAQKPhosphoSitePlus; HPRD
S206PPTLSsTVLIVPhosphoSitePlus
S683NNTVIsQDLDYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T77NQLAStPIIFKPhosphoSitePlus
S70PQRKPsYNQLAPhosphoSitePlus
S3231YQSPLsLCMAKPhosphoSitePlus
T2035NTAIRtPEHLIPhosphoSitePlus
T3193DPKWStPTKDCPhosphoSitePlus
T2967LSRDVtTVWKLPhosphoSitePlus
S193VDPDMsWSSSLPLK1HPRD; phosphoELM; RegPhos
S93LPLYQsPVKELPhosphoSitePlus
Y71QRKPSyNQLASPhosphoSitePlus
S976LKSDIsLNIDKPhosphoSitePlus
Y949KKDLVyVLAEEPhosphoSitePlus
S239SNHDEsLKKNDPhosphoSitePlus

Dephosphorylation site
BRCA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369497I505THPIBreast Cancer11241844
ENSP00000439902E1665QCOSMICLung Cancer20668451
ENSP00000369497R2787HHPI, COSMICOvarian Cancer8665505
ENSP00000369497P3278fs*35COSMICOvarian Cancer21720365
ENSP00000369497C554WHPIBreast Cancer9654203
ENSP00000369497S1982fs*22COSMICPancreatic Cancer
ENSP00000439902C711*TCGAOvarian Cancer21720365, 18772890
ENSP00000369497N1730YHPIBreast Cancer11241844
ENSP00000439902E470QCOSMICOvarian Cancer20668451
ENSP00000369497N2135HHPIBreast Cancer11241844
ENSP00000369497P201RHPIBreast Cancer9609997
ENSP00000369497R18HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369497V2118LHPIBreast Cancer12442275
ENSP00000369497P2096LHPIBreast Cancer14722926
ENSP00000369497G2748DHPIBreast Cancer17924331 21671020
ENSP00000369497F1524VHPIBreast Cancer12938098
ENSP00000369497P3300SHPIEsophageal Cancer11948123
ENSP00000439902D3095ECOSMICBreast Cancer8640235
ENSP00000439902K1638ETCGAOvarian Cancer21720365, 18772890
ENSP00000369497D3095EHPI, COSMICBreast Cancer8640235 17924331
ENSP00000369497V1214fs*14COSMICOvarian Cancer8705994
ENSP00000439902N1287fs*6COSMICIntestines Cancer
ENSP00000369497C315SHPIEsophageal Cancer11948123
ENSP00000369497T2031AHPIBreast Cancer15365993
ENSP00000439902Q407fs*23COSMICOvarian Cancer12237285
ENSP00000369497I1929VHPIBreast Cancer15365993
ENSP00000439902S1882*TCGAOvarian Cancer21720365, 18772890
ENSP00000369497D728AHPIBreast Cancer
ENSP00000439902E1143DCOSMICOvarian Cancer21720365
ENSP00000369497G405RHPIBreast Cancer15026808
ENSP00000369497Y3098HHPIBreast Cancer10486320 15026808
ENSP00000369497S1882*COSMICOvarian Cancer21720365
ENSP00000439902T3357RCOSMICBreast Cancer8640236
ENSP00000369497N1784fs*7COSMICIntestines Cancer17088437
ENSP00000369497G2274VHPIBreast Cancer
ENSP00000369497R118HHPIEsophageal Cancer11948123
ENSP00000369497M192THPIPancreatic Cancer12097290
ENSP00000369497S2072CHPIBreast Cancer12373604
ENSP00000369497P2608fs*40COSMICOvarian Cancer21720365
ENSP00000369497R18HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369497G1771DHPIBreast Cancer12552570 15172753
ENSP00000369497L3333VBIOMARTBreast Cancer21930507, 21930502
ENSP00000369497T1354MCOSMICOvarian Cancer21720365
ENSP00000369497G2837VBIOMARTBreast Cancer21930507, 21930502
ENSP00000439902K1638ECOSMICOvarian Cancer21720365
ENSP00000439902P2608fs*40COSMICOvarian Cancer21720365
ENSP00000369497E187KCOSMICHead and Neck Cancer
ENSP00000369497K1638ETCGAOvarian Cancer21720365, 18772890
ENSP00000439902H2415NCOSMICBreast Cancer8640237
ENSP00000369497G25RHPIBreast Cancer16793542
ENSP00000369497E470QCOSMICOvarian Cancer20668451
ENSP00000369497H1362fs*12COSMICRenal Cancer20054297
ENSP00000369497G2793RHPIBreast Cancer12442275
ENSP00000369497K3196EHPIBreast Cancer11139248
ENSP00000369497K53RHPIBreast Cancer9609997
ENSP00000369497D885fs*10COSMICBreast Cancer8808615
ENSP00000369497N372HBIOMARTGastric Cancer21930507, 21930502
ENSP00000369497E2981KCOSMICMelanoma21499247
ENSP00000369497F81LHPIBreast Cancer9609997
ENSP00000369497D935NHPIBreast Cancer
ENSP00000369497P920SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369497C1580YHPIBreast Cancer11948477
ENSP00000439902P920SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000439902C1853fs*10COSMICOvarian Cancer12237285
ENSP00000369497L613RHPIBreast Cancer12442275
ENSP00000369497T630IHPI, COSMICOvarian Cancer, 8640236
ENSP00000439902T630ICOSMICOvarian Cancer8640236
ENSP00000369497K2128NHPIBreast Cancer12373604
ENSP00000369497E1593*COSMICBreast Cancer
ENSP00000369497E2089DHPIBreast Cancer9150152
ENSP00000369497E880*COSMICOvarian Cancer12237285
ENSP00000369497H2415NHPI, COSMICBreast Cancer8640237
ENSP00000369497E1665QCOSMICLung Cancer20668451
ENSP00000369497S326RHPIBreast Cancer10399947
ENSP00000369497Q2421HHPIBreast Cancer
ENSP00000439902T1354MCOSMICOvarian Cancer21720365
ENSP00000439902T1354MTCGAOvarian Cancer21720365, 18772890
ENSP00000369497P3063SHPIOvarian Cancer14746861
ENSP00000369497P222SHPIBreast Cancer9609997
ENSP00000369497K1638ECOSMICOvarian Cancer21720365
ENSP00000369497R174CBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000369497R2842CHPI, COSMICEsophageal Cancer11948123
ENSP00000439902H1362fs*12COSMICRenal Cancer20054297
ENSP00000369497N1287fs*6COSMICIntestines Cancer
ENSP00000369497I1017STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369497T64IHPIBreast Cancer15172753
ENSP00000369497Y2094CHPIBreast Cancer12373604
ENSP00000369497Y2884*COSMICHead and Neck Cancer21798893
ENSP00000439902E2004QCOSMICLung Cancer18948947
ENSP00000439902S1982fs*22COSMICPancreatic Cancer
ENSP00000439902Q2934*COSMICIntestines Cancer
ENSP00000439902E1593*COSMICBreast Cancer
ENSP00000439902V1988ICOSMICEsophageal Cancer11948123
ENSP00000439902Y2884*COSMICHead and Neck Cancer21798893
ENSP00000369497F2293LHPIBreast Cancer12442275
ENSP00000439902S1882*COSMICOvarian Cancer21720365
ENSP00000439902V355LCOSMICLung Cancer8640236
ENSP00000369497K1690NHPIBreast Cancer15172753
ENSP00000369497T2722ROMIM, HPIBreast Cancer12145750, 12145750 17924331
ENSP00000369497I1017SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369497A75PHPIOvarian Cancer10486320
ENSP00000369497C711*TCGAOvarian Cancer21720365, 18772890
ENSP00000439902V1214fs*14COSMICOvarian Cancer8705994
ENSP00000369497D2723HHPIBreast Cancer15026808 15290653 11207042
ENSP00000369497T431IHPIBreast Cancer12938098
ENSP00000439902Y2977*COSMICPancreatic Cancer
ENSP00000369497S1172LCOSMICHead and Neck Cancer21798897
ENSP00000369497T1354MTCGAOvarian Cancer21720365, 18772890
ENSP00000439902I3103MCOSMICMelanoma8640236
ENSP00000369497I3103MCOSMICMelanoma8640236
ENSP00000369497V211AHPIBreast Cancer9609997
ENSP00000439902R3128*COSMICUterine Cancer
ENSP00000369497I2627FHPIBreast Cancer17924331
ENSP00000369497E462GHPIBreast Cancer12552570 15026808 15172753 19200354
ENSP00000369497R2502CHPIBreast Cancer17924331
ENSP00000439902E2981KCOSMICMelanoma21499247
ENSP00000369497E1901KHPIBreast Cancer14722926
ENSP00000439902R2842CCOSMICEsophageal Cancer11948123
ENSP00000439902P920STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369497S1106RHPIBreast Cancer12938098
ENSP00000439902N1784fs*7COSMICIntestines Cancer17088437
ENSP00000369497Y2977*COSMICPancreatic Cancer
ENSP00000369497G2353RHPIBreast Cancer15026808 21671020
ENSP00000439902C711*COSMICOvarian Cancer21720365
ENSP00000439902P3278fs*35COSMICOvarian Cancer21720365
ENSP00000369497R2659KHPIBreast Cancer17924331
ENSP00000369497N60SHPIBreast Cancer15026808
ENSP00000369497E1593XBIOMARTBreast Cancer21930507, 21930502
ENSP00000369497Q407fs*23COSMICOvarian Cancer12237285
ENSP00000369497T3013IHPIBreast Cancer15026808 15635067
ENSP00000439902E187KCOSMICHead and Neck Cancer
ENSP00000369497N3124IHPIBreast Cancer11139248 20383589
ENSP00000369497R3128*COSMICUterine Cancer
ENSP00000369497K2729NHPIBreast Cancer12442274 21719596 19473207 12750298
ENSP00000439902R2678SCOSMICLung Cancer18948947
ENSP00000369497S2243CCOSMICLung Cancer20668451
ENSP00000369497Q2456EHPIBreast Cancer15172753
ENSP00000369497E1143DCOSMICOvarian Cancer21720365
ENSP00000369497K327EHPIBreast Cancer
ENSP00000439902R2787HCOSMICOvarian Cancer8665505
ENSP00000369497T3357RHPI, COSMICBreast Cancer, 8640236
ENSP00000369497F32LHPIBreast Cancer9609997
ENSP00000369497C1853fs*10COSMICOvarian Cancer12237285
ENSP00000369497S1882*TCGAOvarian Cancer21720365, 18772890
ENSP00000369497Y2222CHPIBreast Cancer11241844
ENSP00000369497V1804AHPIBreast Cancer14722926
ENSP00000369497W31RHPIBreast Cancer16793542
ENSP00000439902I1017SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369497E2275GHPIBreast Cancer15026808
ENSP00000369497S1230fs*9COSMICOvarian Cancer21720365
ENSP00000369497R448HHPIBreast Cancer15026808
ENSP00000439902I1017STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369497R2488KHPIBreast Cancer15026808
ENSP00000439902E880*COSMICOvarian Cancer12237285
ENSP00000369497C711*COSMICOvarian Cancer21720365
ENSP00000369497E2004QDing2008, COSMICLung Cancer18948947
ENSP00000369497S1172LHPIBreast Cancer15635067
ENSP00000439902D885fs*10COSMICBreast Cancer8808615
ENSP00000369497M3118THPIBreast Cancer9609997 11091690
ENSP00000369497E1036KHPIBreast Cancer12938098
ENSP00000369497R2678SDing2008, COSMICLung Cancer18948947
ENSP00000439902R18HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369497V2728IHPIBreast Cancer10399947 10978364 12215251 19861517
ENSP00000369497P920STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000439902R18HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369497T2515IHPIBreast Cancer10978364 12955719
ENSP00000369497T1679IHPIBreast Cancer14722926
ENSP00000439902S1230fs*9COSMICOvarian Cancer21720365
ENSP00000369497L2653PHPIBreast Cancer17924331
ENSP00000369497G1529RHPIUrinary Bladder Cancer21520273
ENSP00000369497V1988IHPI, COSMICEsophageal Cancer11948123
ENSP00000369497I729MHPIBreast Cancer10978364
ENSP00000369497K2950NHPIBreast Cancer15026808 15635067
ENSP00000369497K1445THPIBreast Cancer15365993
ENSP00000369497S1179NHPIBreast Cancer11139248
ENSP00000439902S1172LCOSMICHead and Neck Cancer21798897
ENSP00000369497T1887MHPIBreast Cancer15172753
ENSP00000369497Q2934*COSMICIntestines Cancer
ENSP00000369497Y42CHPIBreast Cancer12442275 14746861 19200354 15290653 12527904
ENSP00000439902S2243CCOSMICLung Cancer20668451
ENSP00000369497V355LHPI, COSMICLung Cancer, 8640236

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000369497Uterine CancerNormal vs. CancertissueDown17902640

Hyperphosphorylation site
BRCA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANBRCA2_HUMANkinase -> substrateRegPhos
PLK1_HUMANBRCA2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03440Homologous recombination
hsa05212Pancreatic cancer
hsa03460Fanconi anemia pathway
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006310DNA recombinationIEAbiological_process
GO:0032465regulation of cytokinesisIEAbiological_process
GO:0008585female gonad developmentIEAbiological_process
GO:0043966histone H3 acetylationIDAbiological_process
GO:0030141secretory granuleIDAcellular_component
GO:0010332response to gamma radiationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010165response to X-rayIEAbiological_process
GO:0000724double-strand break repair via homologous recombinIDAbiological_process
GO:0051298centrosome duplicationIMPbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051276chromosome organizationIEAbiological_process
GO:0010225response to UV-CIEAbiological_process
GO:0042771intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0043009chordate embryonic developmentIEAbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0010484H3 histone acetyltransferase activityIDAmolecular_function
GO:0033593BRCA2-MAGE-D1 complexIDAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0045931positive regulation of mitotic cell cycleIEAbiological_process
GO:0010485H4 histone acetyltransferase activityIDAmolecular_function
GO:0006302double-strand break repairIMPbiological_process
GO:0000724double-strand break repair via homologous recombinIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006978DNA damage response, signal transduction by p53 clIEAbiological_process
GO:0048478replication fork protectionIEAbiological_process
GO:0007141male meiosis IIEAbiological_process
GO:0007090regulation of S phase of mitotic cell cycleNASbiological_process
GO:0033600negative regulation of mammary gland epithelial ceIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030097hemopoiesisIEAbiological_process
GO:0001556oocyte maturationIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001833inner cell mass cell proliferationIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0006289nucleotide-excision repairIMPbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0008630intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0043967histone H4 acetylationIDAbiological_process
GO:0007569cell agingIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0033205cell cycle cytokinesisIDAbiological_process
GO:0003697single-stranded DNA bindingIDAmolecular_function
GO:0043015gamma-tubulin bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component