Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCNB1_HUMAN
Description:cyclin B1 [Source:HGNC Symbol;Acc:1579]
Location:chr5 q13.2
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S128DTASPsPMETSPLK1HPRD; phosphoELM; RegPhos
S116KEEKLsPEPILphosphoELM
S147LCQAFsDVILAPLK1HPRD; phosphoELM; RegPhos
S69KEAKPsATGKVTrypan_PARPPhosphoSitePlus
S133SPMETsGCAPATrypan_PARPPhosphoSitePlus
S133SPMETsGCAPAPLK1HPRD; phosphoELM; RegPhos
S116KEEKLsPEPILTrypan_PARPPhosphoSitePlus
S69KEAKPsATGKVHPRD
S128DTASPsPMETSTrypan_PARPPhosphoSitePlus
T321DVEQHtLAKYLCyclin_CPhosphoSitePlus
S128DTASPsPMETSMAPK_groupphosphoELM; RegPhos
S126LVDTAsPSPMEPLK1HPRD; phosphoELM; RegPhos
Y177KDIYAyLRQLECyclin_NPhosphoSitePlus
S126LVDTAsPSPMETrypan_PARPPhosphoSitePlus
S9RVTRNsKINAEPhosphoSitePlus; HPRD
S126LVDTAsPSPMEMAPK_groupphosphoELM; RegPhos
S147LCQAFsDVILAPhosphoSitePlus
S35APAATsKPGLRPhosphoSitePlus; HPRD
T321DVEQHtLAKYLHPRD

Dephosphorylation site
CCNB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256442*434YCOSMICOvarian Cancer20826764

Differential expressed protein
CCNB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCNB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCNB1_HUMANKAT5_HUMANkinase -> substrateHPRD
CCNB1_HUMANMEF2C_HUMANkinase -> substrateHPRD
CCNB1_HUMANTOPK_HUMANkinase -> substrateHPRD
PLK1_HUMANCCNB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
USF1_HUMANCCNB1_HUMANTF -> target geneTRANSFAC
AP2A_HUMANCCNB1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000922spindle poleIDAcellular_component
GO:0048565digestive tract developmentIEAbiological_process
GO:0042246tissue regenerationIEAbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0051301cell divisionIEAbiological_process
GO:0043148mitotic spindle stabilizationIMPbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0071398cellular response to fatty acidIEAbiological_process
GO:0007080mitotic metaphase plate congressionIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0060623regulation of chromosome condensationIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000942condensed nuclear chromosome outer kinetochoreIDAcellular_component
GO:0071174mitotic cell cycle spindle checkpointIMPbiological_process
GO:0000236mitotic prometaphaseIDAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0001556oocyte maturationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0031442positive regulation of mRNA 3'-end processingIEAbiological_process
GO:0033129positive regulation of histone phosphorylationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0055015ventricular cardiac muscle cell developmentIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0071283cellular response to iron(III) ionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0000278mitotic cell cycleIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0051987positive regulation of attachment of spindle microIMPbiological_process
GO:0006461protein complex assemblyIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleNASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0046680response to DDTIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005113patched bindingIPImolecular_function


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