Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H2B1C_HUMAN
Description:histone cluster 1, H2be [Source:HGNC Symbol;Acc:4753]
Location:chr6 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S15APKKGsKKAVTMST1(STK4RegPhos
S33KKRKRsRKESYHistonePhosphoSitePlus
S37RSRKEsYSVYVHistonePhosphoSitePlus
S65MGIMNsFVNDIHistonePhosphoSitePlus
T91KRSTItSREIQHistonePhosphoSitePlus
T120GTKAVtKYTSSPhosphoSitePlus
S15APKKGsKKAVTPKA_groupphosphoELM; RegPhos
Y41ESYSVyVYKVLHistonePhosphoSitePlus
S124VTKYTsSK___PhosphoSitePlus
S88HYNKRsTITSRHistonePhosphoSitePlus
S7PAPKHPRD
T89YNKRStITSREHistonePhosphoSitePlus
T116AVSEGtKAVTKPhosphoSitePlus
Y38SRKESySVYVYHistonePhosphoSitePlus
Y43YSVYVyKVLKQHistonePhosphoSitePlus
S33KKRKRsRKESYPKA_groupphosphoELM; RegPhos
S113AKHAVsEGTKAPhosphoSitePlus
T53QVHPDtGISSKHistonePhosphoSitePlus
S37RSRKEsYSVYVPKA_groupphosphoELM; RegPhos
S56PDTGIsSKAMGHistonePhosphoSitePlus
Y84SRLAHyNKRSTHistonePhosphoSitePlus
S57DTGISsKAMGIHistonePhosphoSitePlus
S39RKESYsVYVYKHistonePhosphoSitePlus

Dephosphorylation site
H2B1C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348924I90FBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000380180K6NCOSMICOvarian Cancer21720365
ENSP00000321744S79FBIOMARTBreast Cancer21930507, 21930502
ENSP00000380180S79FBIOMARTBreast Cancer21930507, 21930502
ENSP00000353074E77KCOSMICHead and Neck Cancer21798893
ENSP00000244601E114KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353074follicular thyroid carcinomaNormal vs. CancertissueDown0.6118316623
ENSP00000353074follicular thyroid carcinomaNormal vs. CancertissueUp2.518316623
ENSP00000244601Breast CancerNormal vs. CancertissueDown0.4220739354
ENSP00000353074Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
H2B1C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANH2B1C_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05203Viral carcinogenesis
hsa05203Viral carcinogenesis
hsa05203Viral carcinogenesis
hsa05034Alcoholism
hsa05203Viral carcinogenesis
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05203Viral carcinogenesis
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003677DNA bindingNASmolecular_function
GO:0042742defense response to bacteriumIEAbiological_process
GO:0000786nucleosomeNAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0006334nucleosome assemblyNASbiological_process


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