| UniProt/SwissProt ID: | FOXO3_HUMAN |
| Description: | forkhead box O3 [Source:HGNC Symbol;Acc:3821] |
| Location: | chr6 q21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S209 | AGWKNsIRHNL | MST1(STK4 | RegPhos |
| S209 | AGWKNsIRHNL | Fork_head | PhosphoSitePlus |
| S286 | ADDSPsQLSKW | PhosphoSitePlus; HPRD | |
| S280 | QTAPEsADDSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S318 | TNSNAsTVSGR | PhosphoSitePlus; phosphoELM; RegPhos | |
| S588 | LSDSLsGSSLY | PhosphoSitePlus | |
| T32 | RPRSCtWPLQR | PKB_group | phosphoELM |
| S289 | SPSQLsKWPGS | PhosphoSitePlus; HPRD | |
| S555 | LSNSVsNMGLS | PhosphoSitePlus | |
| S7 | APLS | HPRD | |
| S30 | QSRPRsCTWPL | PhosphoSitePlus | |
| S421 | YTTKGsGLGSP | PhosphoSitePlus; phosphoELM | |
| Y184 | TLSQIyEWMVR | Fork_head | PhosphoSitePlus |
| S315 | RSRTNsNASTV | SGK1 | HPRD; RegPhos |
| S243 | PDGGKsGKAPR | Fork_head | PhosphoSitePlus |
| S253 | RRRAVsMDNSN | AKT1 | HPRD; RegPhos |
| S43 | PELQAsPAKPS | PhosphoSitePlus | |
| S231 | EGTGKsSWWII | Fork_head | PhosphoSitePlus |
| S232 | GTGKSsWWIIN | Fork_head | PhosphoSitePlus |
| T319 | NSNAStVSGRL | PhosphoSitePlus | |
| S294 | SKWPGsPTSRS | PhosphoSitePlus | |
| S253 | RRRAVsMDNSN | AKT_group | RegPhos |
| S299 | SPTSRsSDELD | PhosphoSitePlus; HPRD; phosphoELM | |
| S399 | ITLPPsQPSPT | PhosphoSitePlus | |
| S315 | RSRTNsNASTV | PhosphoSitePlus | |
| S551 | GSRALsNSVSN | PhosphoSitePlus | |
| S626 | ECDMEsIIRSE | PhosphoSitePlus | |
| S12 | SPAPLsPLEVE | PhosphoSitePlus; HPRD | |
| T395 | LLDNItLPPSQ | PhosphoSitePlus | |
| S644 | DFNFDsLISTQ | PhosphoSitePlus | |
| T32 | RPRSCtWPLQR | AKT1(PKB) | RegPhos |
| S253 | RRRAVsMDNSN | AKT1(PKB) | RegPhos |
| T32 | RPRSCtWPLQR | SGK1 | HPRD; RegPhos |
| T32 | RPRSCtWPLQR | SGK_group | phosphoELM; RegPhos |
| S644 | DFNFDsLISTQ | IKK_beta | phosphoELM |
| S284 | ESADDsPSQLS | PhosphoSitePlus; HPRD; phosphoELM | |
| T179 | PDKRLtLSQIY | Fork_head | PhosphoSitePlus |
| S321 | NASTVsGRLSP | PhosphoSitePlus; phosphoELM; RegPhos | |
| S7 | AEAPAsPAPLS | PhosphoSitePlus | |
| T32 | RPRSCtWPLQR | PhosphoSitePlus | |
| T32 | RPRSCtWPLQR | AKT_group | RegPhos |
| T427 | GLGSPtSSFNS | PhosphoSitePlus; phosphoELM | |
| S253 | RRRAVsMDNSN | PKB_group | phosphoELM |
| S644 | DFNFDsLISTQ | IKKb(IKK beta | RegPhos |
| S315 | RSRTNsNASTV | SGK_group | phosphoELM; RegPhos |
| S413 | MQRSSsFPYTT | PhosphoSitePlus | |
| S297 | PGSPTsRSSDE | PhosphoSitePlus | |
| S215 | IRHNLsLHSRF | Fork_head | PhosphoSitePlus |
| S253 | RRRAVsMDNSN | SGK_group | phosphoELM; RegPhos |
| S253 | RRRAVsMDNSN | Fork_head | PhosphoSitePlus |
| S344 | DDAPLsPMLYS | PhosphoSitePlus | |
| S439 | VFGPSsLNSLR | PhosphoSitePlus | |
| T32 | RPRSCtWPLQR | AKT1 | HPRD; RegPhos |
| S26 | EFEPQsRPRSC | HPRD | |
| Y162 | WGNLSyADLIT | Fork_head | PhosphoSitePlus |
| S253 | RRRAVsMDNSN | SGK1 | HPRD; RegPhos |
| T296 | WPGSPtSRSSD | PhosphoSitePlus | |
| S425 | GSGLGsPTSSF | PhosphoSitePlus | |
| Dephosphorylation site |
| FOXO3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000385824 | R248W | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000385824 | A6S | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000339527 | R248W | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000385824 | S318C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000339527 | R323H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000385824 | R323H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000339527 | S318C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000339527 | M387I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385824 | G86R | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000339527 | G86R | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000339527 | A6S | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000385824 | M387I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FOXO3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FOXO3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK4_HUMAN | FOXO3_HUMAN | kinase -> substrate | RegPhos |
| IKKB_HUMAN | FOXO3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SGK1_HUMAN | FOXO3_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | FOXO3_HUMAN | kinase -> substrate | RegPhos; NetPath |
| ZAGL2_HUMAN | FOXO3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05223 | Non-small cell lung cancer |
| hsa05213 | Endometrial cancer |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008286 | insulin receptor signaling pathway | IBA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0007389 | pattern specification process | IBA | biological_process |
| GO:0045648 | positive regulation of erythrocyte differentiation | IDA | biological_process |
| GO:0009888 | tissue development | IBA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0008301 | DNA binding, bending | IBA | molecular_function |
| GO:0003690 | double-stranded DNA binding | IBA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0042127 | regulation of cell proliferation | IBA | biological_process |
| GO:0005667 | transcription factor complex | IBA | cellular_component |
| GO:0008134 | transcription factor binding | IBA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0001556 | oocyte maturation | IEA | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IBA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0006417 | regulation of translation | IDA | biological_process |
| GO:0001542 | ovulation from ovarian follicle | IEA | biological_process |
| GO:0051090 | regulation of sequence-specific DNA binding transc | IBA | biological_process |
| GO:0042593 | glucose homeostasis | IEA | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0030330 | DNA damage response, signal transduction by p53 cl | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0009790 | embryo development | IBA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IBA | biological_process |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0001547 | antral ovarian follicle growth | IEA | biological_process |
| GO:0001544 | initiation of primordial ovarian follicle growth | IEA | biological_process |