Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H2B1M_HUMAN
Description:histone cluster 1, H2bm [Source:HGNC Symbol;Acc:4750]
Location:chr6 p22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y84SRLAHyNKRSTHistonePhosphoSitePlus
S113AKHAVsEGTKAPhosphoSitePlus
S124VTKYTsSK___PhosphoSitePlus
S65MGIMNsFVNDIHistonePhosphoSitePlus
Y38SRKESySVYVYHistonePhosphoSitePlus
Y41ESYSVyVYKVLHistonePhosphoSitePlus
T116AVSEGtKAVTKPhosphoSitePlus
Y43YSVYVyKVLKQHistonePhosphoSitePlus
T91KRSTItSREIQHistonePhosphoSitePlus
S33KKRKRsRKESYHistonePhosphoSitePlus
S15VPKKGsKKAINMST1(STK4RegPhos
S88HYNKRsTITSRHistonePhosphoSitePlus
T89YNKRStITSREHistonePhosphoSitePlus
Y122KAVTKyTSSK_PhosphoSitePlus
S39RKESYsVYVYKHistonePhosphoSitePlus
S56PDTGIsSKAMGHistonePhosphoSitePlus
S57DTGISsKAMGIHistonePhosphoSitePlus
S37RSRKEsYSVYVHistonePhosphoSitePlus
T120GTKAVtKYTSSPhosphoSitePlus
T53QVHPDtGISSKHistonePhosphoSitePlus

Dephosphorylation site
H2B1M_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352442Q23*BIOMARTBreast Cancer21930507, 21930502
ENSP00000352442H110YHPIColorectal Cancer16959974
ENSP00000352442H110YSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352442Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000352442Neoplasms by Histologic TypeNormal vs. CancertissueUp712874873
ENSP00000352442Breast CancerNormal vs. Cancercell lineDown0.7320543960
ENSP00000352442Breast CancerNormal vs. Cancercell lineDown0.7520543960

Hyperphosphorylation site
H2B1M_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANH2B1M_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000786nucleosomeNAScellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006334nucleosome assemblyNASbiological_process
GO:0003677DNA bindingNASmolecular_function


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