| UniProt/SwissProt ID: | MK12_HUMAN |
| Description: | mitogen-activated protein kinase 12 [Source:HGNC Symbol;Acc:6874] |
| Location: | chr22 q13.33 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y185 | SEMTGyVVTRW | Pkinase | PhosphoSitePlus |
| S180 | ARQADsEMTGY | Pkinase | PhosphoSitePlus |
| S3 | ___MSsPPPAR | PhosphoSitePlus | |
| S3 | MSSPPpAR | p38g | RegPhos |
| Y27 | EVRAVyRDLQP | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y185 | SEMTGyVVTRW | HPRD; phosphoELM; RegPhos | |
| T183 | ADSEMtGYVVT | MAP2K3 | HPRD; phosphoELM; RegPhos |
| T183 | ADSEMtGYVVT | MAP2K6 | HPRD; phosphoELM; RegPhos |
| T183 | ADSEMtGYVVT | Pkinase | PhosphoSitePlus |
| T183 | ADSEMtGYVVT | RegPhos | |
| S3 | MSSPPpAR | p38g(MAPK12 | RegPhos |
| Y185 | SEMTGyVVTRW | MAP2K3 | phosphoELM; RegPhos |
| Y185 | SEMTGyVVTRW | MAP2K4 | HPRD; phosphoELM; RegPhos |
| Y185 | SEMTGyVVTRW | MAP2K6 | phosphoELM; RegPhos |
| S3 | PPAR | MAPK12 | HPRD; phosphoELM |
| Dephosphorylation site |
| MK12_HUMAN do not have dephosphorylation site. |
| Mutation site |
| MK12_HUMAN do not have mutation site. |
| Differential expressed protein |
| MK12_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y185 | Pkinase | ADSEMTGyVVTRWYR | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MP2K4_HUMAN | MK12_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| CDK5_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | MK12_HUMAN | kinase -> substrate | HPRD |
| MK12_HUMAN | 3BP5_HUMAN | kinase -> substrate | HPRD |
| MAPK5_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | MK12_HUMAN | kinase -> substrate | RegPhos |
| KSYK_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K3_HUMAN | MK12_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK12_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K2_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL5_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | MK12_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| AAPK1_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK1_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| MK12_HUMAN | TAU_HUMAN | kinase -> substrate | HPRD |
| MK08_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LCK_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | SNTA1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK12_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04728 | Dopaminergic synapse |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04912 | GnRH signaling pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa04010 | MAPK signaling pathway |
| hsa05169 | Epstein-Barr virus infection |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa04660 | T cell receptor signaling pathway |
| hsa05133 | Pertussis |
| hsa04370 | VEGF signaling pathway |
| hsa05152 | Tuberculosis |
| hsa05140 | Leishmaniasis |
| hsa04722 | Neurotrophin signaling pathway |
| hsa05132 | Salmonella infection |
| hsa05131 | Shigellosis |
| hsa05164 | Influenza A |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04380 | Osteoclast differentiation |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa04114 | Oocyte meiosis |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05160 | Hepatitis C |
| hsa05145 | Toxoplasmosis |
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0007517 | muscle organ development | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0045786 | negative regulation of cell cycle | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042692 | muscle cell differentiation | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006975 | DNA damage induced protein phosphorylation | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0051149 | positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0045445 | myoblast differentiation | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
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