Human Phosphorylation Mediated
                                 Signaling Transduction Network

Protein information

Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site

Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary

UniProt/SwissProt ID:	LRRC7_HUMAN
Description:	leucine rich repeat containing 7 [Source:HGNC Symbol;Acc:18531]
Location:	chr1 p31.1
Node attribute:	substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S1439	TKGQRsMDGYP	CaMK2a	RegPhos
Y1210	YSTESyGASQT		PhosphoSitePlus
T865	SKLETtPTTSP		RegPhos
T348	SCKNVtVMSLR	LRR_4	PhosphoSitePlus
Y234	LKMLVyLDMSK	LRR_4	PhosphoSitePlus
T602	ENSNPtANTEQ		PhosphoSitePlus
Y1205	LSARSySTESY		PhosphoSitePlus
S949	FKKSQsIDEID		RegPhos
S933	STERLsPLMKD		RegPhos
Y52	TLEELyLDANQ	LRR_4	PhosphoSitePlus
S850	WTRTPsPFEDR		RegPhos
S1163	VTVTEsQFLKR		PhosphoSitePlus
Y572	RYPTPyPEDLK		PhosphoSitePlus
S1439	TKGQRsMDGYP		RegPhos
S1439	TKGQRsMDGYP	CAMK2A	HPRD
T1370	PPDTItKKAGS		PhosphoSitePlus
S90	PTTIAsLVNLK		RegPhos
S708	RVKVGsLQTTA		PhosphoSitePlus; HPRD
T570	LKRYPtPYPED		PhosphoSitePlus
T856	PFEDRtAFPSK		PhosphoSitePlus
S351	NVTVMsLRSNK	LRR_4	PhosphoSitePlus
S1491	PDGPAsNLLQP	PDZ	PhosphoSitePlus
T411	LIPLQtEAHPE		HPRD
S343	PREIGsCKNVT		PhosphoSitePlus
T1161	SSVTVtESQFL		PhosphoSitePlus
T1368	DVPPDtITKKA		PhosphoSitePlus
T711	VGSLQtTAKDA		HPRD
S1156	GLDRQsSVTVT		PhosphoSitePlus
T1215	YGASQtRPVSA		PhosphoSitePlus
Y1179	DEHPSyQEVKA		PhosphoSitePlus

Dephosphorylation site

LRRC7_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000035383	V1364E	COSMIC	Ovarian Cancer	21720365
ENSP00000035383	A1021S	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	R353C	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	P1496H	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	R703P	COSMIC	Ovarian Cancer	21720365
ENSP00000035383	L235M	Sjoblom2006, COSMIC, HPI	Breast Cancer	16959974
ENSP00000035383	R703P	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	D938H	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	Y687*	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	A1021S	COSMIC	Ovarian Cancer	21720365
ENSP00000309245	T870N	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	R72G	COSMIC	Ovarian Cancer	21720365
ENSP00000035383	G1344E	COSMIC	Skin Cancer	21984974
ENSP00000035383	D938H	COSMIC	Ovarian Cancer	21720365
ENSP00000309245	S35C	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	N719K	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	S1204T	COSMIC	Head and Neck Cancer	21798893
ENSP00000035383	D1141N	COSMIC	Ovarian Cancer	20826764
ENSP00000035383	S30C	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	N719K	COSMIC	Ovarian Cancer	21720365
ENSP00000035383	T865N	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	A413V	COSMIC	Head and Neck Cancer	21984974
ENSP00000309245	Y692*	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	V1364E	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000035383	Q1326E	COSMIC	Head and Neck Cancer	21798893
ENSP00000309245	R358C	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000035383	P1496H	COSMIC	Ovarian Cancer	21720365
ENSP00000035383	G1497R	COSMIC	Hepatocellular Carcinoma
ENSP00000035383	N240fs*3	COSMIC	Breast Cancer	16959974
ENSP00000035383	S1063T	COSMIC	Central Nervous System Neoplasms	18772396

Differential expressed protein

LRRC7_HUMAN is not differential expressed protein.

Hyperphosphorylation site

LRRC7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
KCC2A_HUMAN	LRRC7_HUMAN	kinase -> substrate	HPRD
ZAGL2_HUMAN	LRRC7_HUMAN	kinase -> substrate	RegPhos

Function Annotation

KEGG Pathway

LRRC7_HUMAN is not in KEGG pathway.

Gene Ontology

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