Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLK3_HUMAN
Description:polo-like kinase 3 [Source:HGNC Symbol;Acc:2154]
Location:chr1 p34.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y136DADNIyIFLELPkinasePhosphoSitePlus
T194GNFFItENMELPkinasePhosphoSitePlus

Dephosphorylation site
PLK3_HUMAN do not have dephosphorylation site.

Mutation site
PLK3_HUMAN do not have mutation site.

Differential expressed protein
PLK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLK3_HUMANP53_HUMANkinase -> substrateHPRD; RegPhos
PLK3_HUMANMPIP3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK3_HUMANVRK1_HUMANkinase -> substrateHPRD
PLK3_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
PLK3_HUMANCHK2_HUMANkinase -> substrateHPRD; RegPhos
PLK3_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
PLK3_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
PLK3_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0009314response to radiationIDAbiological_process
GO:0007113endomitotic cell cycleTASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043491protein kinase B signaling cascadeISSbiological_process
GO:0000910cytokinesisTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006970response to osmotic stressIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000302response to reactive oxygen speciesIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:2000777positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005795Golgi stackIDAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0071780mitotic cell cycle G2/M transition checkpointTASbiological_process
GO:0002039p53 bindingIDAmolecular_function
GO:0071779G1/S transition checkpointISSbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0090166Golgi disassemblyIDAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000084S phase of mitotic cell cycleIMPbiological_process
GO:0005737cytoplasmIDAcellular_component


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