| UniProt/SwissProt ID: | DGKA_HUMAN |
| Description: | diacylglycerol kinase, alpha 80kDa [Source:HGNC Symbol;Acc:2849] |
| Location: | chr12 q13.2 |
| Node attribute: | Enzyme(source); Enzyme(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y50 | GDAIGyEGFQQ | PhosphoSitePlus | |
| S23 | KYMEYsTKKVS | PhosphoSitePlus | |
| Y335 | PPSSIyPSVLA | PhosphoSitePlus | |
| T24 | YMEYStKKVSD | PhosphoSitePlus | |
| T670 | MGQIYtKLKNA | DAGK_acc | PhosphoSitePlus |
| Y218 | FPRPVyCNLCE | C1_1; Prok-RING_1 | PhosphoSitePlus |
| Y623 | PHGDIyGINQA | DAGK_acc | PhosphoSitePlus |
| Y669 | EMGQIyTKLKN | DAGK_acc | PhosphoSitePlus |
| Y22 | QKYMEySTKKV | PhosphoSitePlus; HPRD; phosphoELM | |
| T637 | TAKVItDPDIL | DAGK_acc | PhosphoSitePlus |
| Dephosphorylation site |
| DGKA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000450359 | E700D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377703 | D621N | COSMIC | Skin Cancer | 21984974 | ENSP00000450359 | E700D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000450359 | N601T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000450359 | D283Y | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000328405 | N601T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000328405 | D283Y | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000328405 | P331L | COSMIC | Skin Cancer | 21984974 | ENSP00000377703 | E700D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377703 | N601T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000450359 | V379I | COSMIC | Pancreatic Cancer | ENSP00000328405 | E700D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000328405 | V379I | COSMIC | Pancreatic Cancer | ENSP00000328405 | E700D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000328405 | V27L | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000450359 | D621N | COSMIC | Skin Cancer | 21984974 | ENSP00000377703 | E700D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000328405 | D621N | COSMIC | Skin Cancer | 21984974 | ENSP00000377703 | D283Y | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000377703 | P331L | COSMIC | Skin Cancer | 21984974 | ENSP00000450359 | P331L | COSMIC | Skin Cancer | 21984974 | ENSP00000377703 | V379I | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| DGKA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DGKA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CHK2_HUMAN | DGKA_HUMAN | enzyme catalysis | KEGG |
| DGKA_HUMAN | PLCD3_HUMAN | enzyme catalysis | KEGG |
| PLCD3_HUMAN | DGKA_HUMAN | enzyme catalysis | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00561 | Glycerolipid metabolism |
| hsa01100 | Metabolic pathways |
| hsa00564 | Glycerophospholipid metabolism |
| hsa04070 | Phosphatidylinositol signaling system |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004143 | diacylglycerol kinase activity | IEA | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0007205 | protein kinase C-activating G-protein coupled rece | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |