Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MRF_HUMAN
Description:myelin regulatory factor [Source:HGNC Symbol;Acc:1181]
Location:chr11 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T319IARVQtPPWHPPhosphoSitePlus
S329PPGAPsPGLLQPhosphoSitePlus
S938NIRAKsWGLSVPhosphoSitePlus
S782AFSVVsMSTLYTMPhosphoSitePlus
Y343SLSGSyLDPNYPhosphoSitePlus
Y147SGSEAySPQQVPhosphoSitePlus
S1103DTQGTsHRWPIPhosphoSitePlus
Y198PPPPHyPVLQRPhosphoSitePlus
T768RFLQGtIIALVPhosphoSitePlus
T1102QDTQGtSHRWPPhosphoSitePlus
S1079LCSLRsKEEPCPhosphoSitePlus

Dephosphorylation site
MRF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000278836N974TBIOMARTBreast Cancer21930507, 21930502
ENSP00000265460N939TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MRF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MRF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGFR2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
VRK1_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
AURKC_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
PDK1L_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
NEK11_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MRF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0022010central nervous system myelinationISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0032286central nervous system myelin maintenanceISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0031643positive regulation of myelinationISSbiological_process
GO:0014003oligodendrocyte developmentISSbiological_process
GO:0005634nucleusISScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0048709oligodendrocyte differentiationISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function


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