Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK6_HUMAN
Description:cyclin-dependent kinase 6 [Source:HGNC Symbol;Acc:1777]
Location:chr7 q21.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T70LRHLEtFEHPNPkinasePhosphoSitePlus
Y24IGEGAyGKVFKPkinasePhosphoSitePlus
S57EGMPLsTIREVPkinasePhosphoSitePlus
S223LFRGSsDVDQLPkinasePhosphoSitePlus
S155NILVTsSGQIKPkinasePhosphoSitePlus
Y299ALSHPyFQDLEPkinasePhosphoSitePlus
Y13RADQQyECVAEPkinasePhosphoSitePlus
Y24IGEGAyGKVFKHPRD; phosphoELM
Y292KRISAySALSHPkinasePhosphoSitePlus
T49RVRVQtGEEGMPkinasePhosphoSitePlus
Y13RADQQyECVAEHPRD; phosphoELM
S86DVCTVsRTDREPkinasePhosphoSitePlus
S293RISAYsALSHPPkinasePhosphoSitePlus
T325TSELNtA____PhosphoSitePlus
S296AYSALsHPYFQPkinasePhosphoSitePlus
S222PLFRGsSDVDQPkinasePhosphoSitePlus
T177FQMALtSVVVTPkinasePhosphoSitePlus

Dephosphorylation site
CDK6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265734P199LGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
CDK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDK6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK6_HUMANSET_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANPUM1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANMAGA6_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCTNB1_HUMANkinase -> substrateHPRD; RegPhos
CDK6_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANTFE2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRNF14_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANZN410_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRBL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK6_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANLRIG1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANCDK6_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRB_HUMANkinase -> substrateNetPath
CDK6_HUMANNUSAP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia
hsa05212Pancreatic cancer
hsa05203Viral carcinogenesis
hsa05162Measles
hsa04115p53 signaling pathway
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
hsa05218Melanoma
hsa04110Cell cycle
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0021670lateral ventricle developmentISSbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0048146positive regulation of fibroblast proliferationIMPbiological_process
GO:0043697cell dedifferentiationIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0021542dentate gyrus developmentISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0048699generation of neuronsISSbiological_process
GO:0001954positive regulation of cell-matrix adhesionIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0009615response to virusIEPbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIMPbiological_process
GO:0003323type B pancreatic cell developmentIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0004693cyclin-dependent protein kinase activityIDAmolecular_function
GO:0045638negative regulation of myeloid cell differentiatioIDAbiological_process
GO:0010468regulation of gene expressionIDAbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:2000145regulation of cell motilityISSbiological_process
GO:0051301cell divisionIEAbiological_process
GO:2000773negative regulation of cellular senescenceIDAbiological_process
GO:0000080G1 phase of mitotic cell cycleIEPbiological_process
GO:0005829cytosolTAScellular_component
GO:0030332cyclin bindingIPImolecular_function
GO:0014002astrocyte developmentISSbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000307cyclin-dependent protein kinase holoenzyme complexIDAcellular_component
GO:0060218hematopoietic stem cell differentiationIEAbiological_process
GO:0042063gliogenesisIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0002244hematopoietic progenitor cell differentiationIEAbiological_process
GO:0045596negative regulation of cell differentiationTASbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0001726ruffleIDAcellular_component
GO:0045668negative regulation of osteoblast differentiationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045646regulation of erythrocyte differentiationIMPbiological_process