Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PUM1_HUMAN
Description:pumilio homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:14957]
Location:chr1 p35.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1154ATLRKyTYGKHPhosphoSitePlus
Y717GSSDLyKRTSSPhosphoSitePlus
T112KHRWPtGDNIHPhosphoSitePlus
S98LGGGGsGGGGYPhosphoSitePlus; HPRD
Y784NGSGRyISAAPPhosphoSitePlus
S228EYVLSsSPGDSPhosphoSitePlus; HPRD; phosphoELM
T711RRDSLtGSSDLPhosphoSitePlus; HPRD; phosphoELM
S197RRPGQsFHVNSPhosphoSitePlus; HPRD
Y795GAEAKyRSASSPhosphoSitePlus
S106GGYNNsKHRWPPhosphoSitePlus; HPRD
S229YVLSSsPGDSCPhosphoSitePlus; HPRD; phosphoELM
T60ALAAGtHSSPVHPRD
T810FSPSStLFSSSPhosphoSitePlus
S209VNSVLsPRSESPhosphoSitePlus; HPRD; phosphoELM
T514SQRPLtPNQNQPhosphoSitePlus
S814STLFSsSRLRYPhosphoSitePlus
S806ASSLFsPSSTLPhosphoSitePlus; HPRD; phosphoELM
S202SFHVNsEVNSVHPRD
S809LFSPSsTLFSSPhosphoSitePlus
S75GVAGRsQDDAMPhosphoSitePlus; HPRD; phosphoELM
Y1168KLEKYyMKNGVPhosphoSitePlus
S797EAKYRsASSASPhosphoSitePlus
T39MPVVLtSGTGSHPRD
S124EHQVRsMDELNPhosphoSitePlus; HPRD
T1150RPHIAtLRKYTPhosphoSitePlus
Y83DAMVDyFFQRQPhosphoSitePlus
Y1123DQYANyVVQKMPUFPhosphoSitePlus
Y103SGGGGyNNSKHHPRD
S713DSLTGsSDLYKPhosphoSitePlus
S17VLWQDsFSPHLHPRD; phosphoELM
S709GSRRDsLTGSSPhosphoSitePlus; HPRD; phosphoELM
S206NSEVNsVLSPRPhosphoSitePlus
S714SLTGSsDLYKRPhosphoSitePlus; HPRD
S808SLFSPsSTLFSPhosphoSitePlus; HPRD; phosphoELM
Y1113PHSALyTMMKDPUFPhosphoSitePlus
S19WQDSFsPHLKHPhosphoSitePlus; HPRD; phosphoELM
Y1120MMKDQyANYVVPUFPhosphoSitePlus

Dephosphorylation site
PUM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000401777N307SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000257075G231DCOSMICCentral Nervous System Neoplasms18772396
ENSP00000257075N307SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000257075N1080SCOSMICHead and Neck Cancer21798893
ENSP00000257075A688TCOSMICPancreatic Cancer
ENSP00000257075D244NCOSMICSkin Cancer21984974
ENSP00000257075S657GCOSMICOvarian Cancer21720365
ENSP00000257075E848KCOSMICCentral Nervous System Neoplasms21817013
ENSP00000257075K256RCOSMICOvarian Cancer21720365

Differential expressed protein
PUM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PUM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK6_HUMANPUM1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANPUM1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PUM1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006417regulation of translationIEAbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0016044cellular membrane organizationTASbiological_process
GO:0006892post-Golgi vesicle-mediated transportTASbiological_process
GO:0005829cytosolTAScellular_component


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