Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RIPK1_HUMAN
Description:receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:HGNC Symbol;Acc:10019]
Location:chr6 p25.2
Node attribute:cleavage(target); deubiquitination(target); ubiquitination(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S25SAELDsGGFGKPkinase_TyrPhosphoSitePlus
Y469QNNGLySSHGFPhosphoSitePlus
S346GSLHSsQGLGMHPRD; phosphoELM
S20SDFLEsAELDSPhosphoSitePlus
T337RSNSAtEQPGSHPRD; phosphoELM
S320VKRMQsLQLDCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y463QPQVLyQNNGLPhosphoSitePlus
S161DLGLAsFKMWSPkinase_TyrPhosphoSitePlus
S166SFKMWsKLNNEPkinase_TyrPhosphoSitePlus
Y426AQQRPyENFQNPhosphoSitePlus
Y490GPRVWyRPIPSPhosphoSitePlus
S330CVAVPsSRSNSPhosphoSitePlus
Y387ANYHLyGSRMDPhosphoSitePlus; HPRD; phosphoELM
S32GFGKVsLCFHRPkinase_TyrPhosphoSitePlus
S389YHLYGsRMDRQPhosphoSitePlus; HPRD; phosphoELM
S416RRRRVsHDPFAPhosphoSitePlus
S14VIKMKsSDFLEPhosphoSitePlus
Y384QDEANyHLYGSPhosphoSitePlus; HPRD; phosphoELM
T483PLDPGtAGPRVPhosphoSitePlus
S333VPSSRsNSATEPhosphoSitePlus
S470NNGLYsSHGFGPhosphoSitePlus
S15IKMKSsDFLESPhosphoSitePlus
S303EEDVKsLKKEYPhosphoSitePlus
T38LCFHRtQGLMIPkinase_TyrPhosphoSitePlus
S6MQPDMsLNVIKPhosphoSitePlus
S331VAVPSsRSNSAPhosphoSitePlus
S471NGLYSsHGFGTPhosphoSitePlus

Dephosphorylation site
RIPK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369773Q379*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000369773A64VHPIColorectal Cancer17344846
ENSP00000369773V81IGreenman2007Intestines Cancer17344846, 18428421
ENSP00000259808Q379*Ding2008Lung Cancer18948947
ENSP00000259808A64VGreenman2007Intestines Cancer17344846, 18428421
ENSP00000259808V81IHPIColorectal Cancer17344846
ENSP00000369773A220VGreenman2007Intestines Cancer17344846, 18428421
ENSP00000259808A64VHPIColorectal Cancer17344846
ENSP00000369773A220VHPIColorectal Cancer17344846
ENSP00000259808V81IGreenman2007Intestines Cancer17344846, 18428421
ENSP00000369773A64VGreenman2007Intestines Cancer17344846, 18428421
ENSP00000259808A220VHPIColorectal Cancer17344846
ENSP00000259808A220VGreenman2007Intestines Cancer17344846, 18428421
ENSP00000369773V81IHPIColorectal Cancer17344846
ENSP00000259808D156NBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
RIPK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RIPK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RIPK3_HUMANRIPK1_HUMANkinase -> substrateNetPath
RIPK1_HUMANM3K1_HUMANkinase -> substrateNetPath
RFFL_HUMANRIPK1_HUMANkinase -> substrateNetPath
RIPK1_HUMANRIPK1_HUMANkinase -> substrateNetPath
BIRC2_HUMANRIPK1_HUMANubiquitinationNetPath
TNAP3_HUMANRIPK1_HUMANubiquitinationNetPath
RFFL_HUMANRIPK1_HUMANubiquitinationNetPath
TRAF2_HUMANRIPK1_HUMANubiquitinationNetPath
TNAP3_HUMANRIPK1_HUMANdeubiquitinationNetPath
CASP8_HUMANRIPK1_HUMANcleavageNetPath
RIPK1_HUMANTRAF6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05169Epstein-Barr virus infection
hsa04210Apoptosis
hsa04622RIG-I-like receptor signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0043068positive regulation of programmed cell deathIMPbiological_process
GO:0060555activation of necroptosis by extracellular signalsIMPbiological_process
GO:0005123death receptor bindingIPImolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0010940positive regulation of necrotic cell deathIMPbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0070926regulation of ATP:ADP antiporter activityIMPbiological_process
GO:2001237negative regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0033209tumor necrosis factor-mediated signaling pathwayICbiological_process
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0051260protein homooligomerizationIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0043235receptor complexIDAcellular_component
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0060545positive regulation of necroptosisIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034612response to tumor necrosis factorIMPbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0006917induction of apoptosisIMPbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0042327positive regulation of phosphorylationIEAbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0032760positive regulation of tumor necrosis factor produIDAbiological_process
GO:2000379positive regulation of reactive oxygen species metTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0010008endosome membraneTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:2001243negative regulation of intrinsic apoptotic signaliIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0031264death-inducing signaling complexIDAcellular_component
GO:0070513death domain bindingIPImolecular_function