Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLMN_HUMAN
Description:plasminogen [Source:HGNC Symbol;Acc:9071]
Location:chr6 q26
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S597WPWQVsLRTRFHPRD; phosphoELM
Y111GNGKNyRGTMSKringlePhosphoSitePlus
T678SPAVItDKVIPTrypsinPhosphoSitePlus
S597WPWQVsLRTRFTrypsinPhosphoSitePlus
T200GKISKtMSGLEKringlePhosphoSitePlus
T662LFLEPtRKDIATrypsinPhosphoSitePlus
Y99FEKKVyLSECKPhosphoSitePlus

Dephosphorylation site
PLMN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308938H67YCOSMICMelanoma21499247
ENSP00000308938G278RCOSMICSkin Cancer21984974
ENSP00000308938S351TBIOMARTBrain Cancer21930507, 21930502
ENSP00000308938G761RCOSMICSkin Cancer21984974
ENSP00000308938G195SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000308938G395RCOSMICSkin Cancer21984974
ENSP00000308938Y416FCOSMICOvarian Cancer21720365
ENSP00000308938G106RCOSMICHead and Neck Cancer21798893
ENSP00000308938C73YBIOMARTBreast Cancer21930507, 21930502
ENSP00000308938A750VCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000308938hepatitis C virusNormal vs. CancertissueUp3.818715028
ENSP00000308938Pancreatic CancerNormal vs. CancertissueUp1.916212428
ENSP00000308938Brain CancerNormal vs. CancertissueUp2.418056677

Hyperphosphorylation site
PLMN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANPLMN_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANPLMN_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PLMN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060707trophoblast giant cell differentiationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0006508proteolysisIEAbiological_process
GO:0051919positive regulation of fibrinolysisIDAbiological_process
GO:0042246tissue regenerationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071674mononuclear cell migrationIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0031232extrinsic to external side of plasma membraneIDAcellular_component
GO:2000048negative regulation of cell-cell adhesion mediatedTASbiological_process
GO:0043498cell surface bindingIDAmolecular_function
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0051918negative regulation of fibrinolysisIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0048771tissue remodelingIEAbiological_process
GO:0004252serine-type endopeptidase activityIDAmolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0060716labyrinthine layer blood vessel developmentIEAbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0051603proteolysis involved in cellular protein catabolicIEAbiological_process
GO:0019897extrinsic to plasma membraneIEAcellular_component
GO:0007596blood coagulationIMPbiological_process
GO:0042730fibrinolysisTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0034185apolipoprotein bindingIPImolecular_function
GO:0022617extracellular matrix disassemblyIDAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0030198extracellular matrix organizationTASbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0010812negative regulation of cell-substrate adhesionIDAbiological_process
GO:0045445myoblast differentiationIEAbiological_process


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