| UniProt/SwissProt ID: | RAB5C_HUMAN |
| Description: | RAB5C, member RAS oncogene family [Source:HGNC Symbol;Acc:9785] |
| Location: | chr17 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S140 | KADLAsKRAVE | Ras | PhosphoSitePlus |
| Y83 | AGQERyHSLAP | Ras | PhosphoSitePlus |
| S85 | QERYHsLAPMY | Ras | PhosphoSitePlus |
| S124 | LQRQAsPNIVI | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RAB5C_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377440 | R40H | HPI | Colorectal Cancer | 16959974 | ENSP00000345689 | R40H | HPI | Colorectal Cancer | 16959974 | ENSP00000345689 | R40H | COSMIC | Intestines Cancer | 16959974 | ENSP00000377440 | R40H | COSMIC | Intestines Cancer | 16959974 | ENSP00000377440 | G93R | COSMIC | Melanoma | ENSP00000345689 | G93R | COSMIC | Melanoma |
| Differential expressed protein |
| RAB5C_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAB5C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANPRB_HUMAN | RAB5C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | RAB5C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RAB5C_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005811 | lipid particle | IDA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0030100 | regulation of endocytosis | IEA | biological_process |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0007032 | endosome organization | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0030139 | endocytic vesicle | IEA | cellular_component |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |