Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACOC_HUMAN
Description:aconitase 1, soluble [Source:HGNC Symbol;Acc:117]
Location:chr9 p21.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y466LNVMPyIKTSLHPRD
S138NRRADsLQKNQHPRD; phosphoELM
S711FNSYGsRRGNDPKC_alphaphosphoELM
S138NRRADsLQKNQPKC_alphaphosphoELM
S711FNSYGsRRGNDHPRD
S383DKVAVsDMKKDAconitasePhosphoSitePlus
T628WNALAtPSDKLPhosphoSitePlus
S711FNSYGsRRGNDAconitase_CPhosphoSitePlus
S806ERIHRsNLVGMAconitase_CPhosphoSitePlus
T258PLVTStDIVLTAconitasePhosphoSitePlus
Y759DAAERyQQAGLAconitase_CPhosphoSitePlus
Y336KYIKKyLQAVGAconitasePhosphoSitePlus
T318DEVSItYLVQTAconitasePhosphoSitePlus
S138NRRADsLQKNQAconitasePhosphoSitePlus
Y466LNVMPyIKTSLAconitasePhosphoSitePlus
Y184QVNLEyLARVVAconitasePhosphoSitePlus
S622ETVNEsWNALAPhosphoSitePlus

Dephosphorylation site
ACOC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309477V123LCOSMICOvarian Cancer21720365
ENSP00000369255V123LCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000369255hepatitis C virusNormal vs. CancertissueDown0.318715028
ENSP00000369255Hepatocellular CarcinomaNormal vs. CancertissueDown18571811
ENSP00000369255Hepatocellular CarcinomaCancer vs. CancertissueDown20038311
ENSP00000369255Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000369255Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000369255Breast CancerMetastasiscell lineUp1.320052998

Hyperphosphorylation site
ACOC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANACOC_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANACOC_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANACOC_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
hsa00630Glyoxylate and dicarboxylate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusIDAcellular_component
GO:0030350iron-responsive element bindingIDAmolecular_function
GO:0052633isocitrate hydro-lyase (cis-aconitate-forming) actIEAmolecular_function
GO:0003994aconitate hydratase activityIDAmolecular_function
GO:0006099tricarboxylic acid cycleIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0009791post-embryonic developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0008152metabolic processIEAbiological_process
GO:0006417regulation of translationIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0050892intestinal absorptionIEAbiological_process
GO:0010040response to iron(II) ionIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0003723RNA bindingNASmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0052632citrate hydro-lyase (cis-aconitate-forming) activiIEAmolecular_function
GO:0006101citrate metabolic processIDAbiological_process


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