Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYCP2_HUMAN
Description:synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:11490]
Location:chr20 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1241HINENyIQSKRPhosphoSitePlus
Y1140KSISPyPKTSSPhosphoSitePlus
S1040CEQEFsHSFKEPhosphoSitePlus
S1138ITKSIsPYPKTPhosphoSitePlus
T1019LPRKAtKTKKNPhosphoSitePlus
S543SLKSRsSEGRHPhosphoSitePlus
S1111SGSPSsIEVTRPhosphoSitePlus
Y1130DFTQDyDCITKPhosphoSitePlus
S544LKSRSsEGRHRPhosphoSitePlus
S436GEELVsLKEKSPhosphoSitePlus
T470SQLEKtTPSKRHPRD; SysPTM
T471QLEKTtPSKRKPhosphoSitePlus
T1021RKATKtKKNYKPhosphoSitePlus
T501VLFSNtSIPPRPhosphoSitePlus
S1110LSGSPsSIEVTPhosphoSitePlus
S478SKRKMsEASMIPhosphoSitePlus
T1060HSRMKtVKLPKPhosphoSitePlus
S1056EENIHsRMKTVPhosphoSitePlus
S1042QEFSHsFKENIPhosphoSitePlus
S1523MSVFMsHERNAPhosphoSitePlus

Dephosphorylation site
SYCP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350162K474NCOSMICHead and Neck Cancer21798893
ENSP00000350162R542TBIOMARTBreast Cancer21930507, 21930502
ENSP00000350162N193ICOSMICHead and Neck Cancer21798893
ENSP00000360040R542TBIOMARTBreast Cancer21930507, 21930502
ENSP00000350162K1427*COSMICOvarian Cancer21720365
ENSP00000350162S1234CBIOMARTBreast Cancer21930507, 21930502
ENSP00000360040R509KBIOMARTBreast Cancer21930507, 21930502
ENSP00000360040S1234CBIOMARTBreast Cancer21930507, 21930502
ENSP00000350162K1315RCOSMICLung Cancer20668451
ENSP00000350162S1161LCOSMICOvarian Cancer21720365
ENSP00000350162R509KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360040Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineUp8.816900703
ENSP00000360040Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineUp14997504

Hyperphosphorylation site
SYCP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANSYCP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SYCP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000800lateral elementIEAcellular_component
GO:0003677DNA bindingNASmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0007130synaptonemal complex assemblyNASbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048808male genitalia morphogenesisIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0007140male meiosisIEAbiological_process
GO:0005634nucleusNAScellular_component
GO:0007128meiotic prophase INASbiological_process
GO:0007143female meiosisIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0000795synaptonemal complexIEAcellular_component
GO:0000795synaptonemal complexNAScellular_component
GO:0009566fertilizationIEAbiological_process


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