Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:F262_HUMAN
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [Source:HGNC Symbol;Acc:8873]
Location:chr1 q32.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S471SFTPLsSSNTIPhosphoSitePlus; HPRD; phosphoELM
T475LSSSNtIRRPRPRKCAHPRD
S483RPRNYsVGSRPAKT1HPRD; RegPhos; SysPTM
S486NYSVGsRPLKPPhosphoSitePlus; HPRD; phosphoELM
Y482RRPRNySVGSRPhosphoSitePlus
S466RMRRNsFTPLSPRKACAHPRD; SysPTM
T458FPKNQtPVRMRPhosphoSitePlus
S483RPRNYsVGSRPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y366PGGESyQDLVQHis_Phos_1PhosphoSitePlus
T475LSSSNtIRRPRPKC_group RegPhos
S466RMRRNsFTPLSPRKAA2HPRD; SysPTM
S466RMRRNsFTPLSPRKAA1HPRD; SysPTM
Y358QEKYLyRYPGGHis_Phos_1PhosphoSitePlus
S483RPRNYsVGSRPPKB_groupphosphoELM; SysPTM
S466RMRRNsFTPLSPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S483RPRNYsVGSRPAKT_groupRegPhos; SysPTM
S466RMRRNsFTPLSAKT_groupRegPhos; SysPTM
S466RMRRNsFTPLSAMPKa1RegPhos; SysPTM
S466RMRRNsFTPLSAMPKa2RegPhos; SysPTM
S29SEKKCsWASYMHPRD
S493PLKPLsPLRAQPhosphoSitePlus; HPRD; phosphoELM
S466RMRRNsFTPLSPKACaRegPhos; SysPTM
S466RMRRNsFTPLSPKB_groupphosphoELM; SysPTM
Y356RDQEKyLYRYPHis_Phos_1PhosphoSitePlus
T475LSSSNtIRRPRPKCaRegPhos
T475LSSSNtIRRPRPhosphoSitePlus; phosphoELM
S466RMRRNsFTPLSAMPK_groupphosphoELM; RegPhos; SysPTM
T468RRNSFtPLSSSPhosphoSitePlus; HPRD; phosphoELM
S32KCSWAsYMTNS6PF2KPhosphoSitePlus
S29SEKKCsWASYMPKA_group RegPhos
S466RMRRNsFTPLSAKT1HPRD; RegPhos; SysPTM
S32KCSWAsYMTNSHPRD

Dephosphorylation site
F262_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356046A109STCGAOvarian Cancer21720365, 18772890
ENSP00000356047A109SCOSMICOvarian Cancer21720365

Differential expressed protein
F262_HUMAN is not differential expressed protein.

Hyperphosphorylation site
F262_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK1_HUMANF262_HUMANkinase -> substrateHPRD
KPCA_HUMANF262_HUMANkinase -> substrateHPRD
AKT1_HUMANF262_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANF262_HUMANkinase -> substrateRegPhos
AAPK2_HUMANF262_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00051Fructose and mannose metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044281small molecule metabolic processTASbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:00038736-phosphofructo-2-kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0033133positive regulation of glucokinase activityIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0006003fructose 2,6-bisphosphate metabolic processIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006007glucose catabolic processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0019900kinase bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006006glucose metabolic processTASbiological_process
GO:0006000fructose metabolic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activityIEAmolecular_function
GO:0006090pyruvate metabolic processIEAbiological_process
GO:0006089lactate metabolic processIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0006096glycolysisIDAbiological_process


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