Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP6_HUMAN
Description:caspase 6, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1507]
Location:chr4 q25
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S257VNRKVsQRRVDRegPhos
S257VNRKVsQRRVDAMPK_groupphosphoELM; RegPhos
S257VNRKVsQRRVDPeptidase_C14PhosphoSitePlus
S257VNRKVsQRRVDNuaK1phosphoELM; RegPhos
S257VNRKVsQRRVDNUAK1HPRD

Dephosphorylation site
CASP6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265164M19RCOSMICOvarian Cancer21720365

Differential expressed protein
CASP6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASP6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCASP6_HUMANkinase -> substrateRegPhos
NUAK1_HUMANCASP6_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
AAPK2_HUMANCASP6_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008234cysteine-type peptidase activityTASmolecular_function
GO:0006508proteolysisIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0004197cysteine-type endopeptidase activityTASmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0006508proteolysisIEAbiological_process


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