| UniProt/SwissProt ID: | CASP6_HUMAN |
| Description: | caspase 6, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1507] |
| Location: | chr4 q25 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S257 | VNRKVsQRRVD | RegPhos | |
| S257 | VNRKVsQRRVD | AMPK_group | phosphoELM; RegPhos |
| S257 | VNRKVsQRRVD | Peptidase_C14 | PhosphoSitePlus |
| S257 | VNRKVsQRRVD | NuaK1 | phosphoELM; RegPhos |
| S257 | VNRKVsQRRVD | NUAK1 | HPRD |
| Dephosphorylation site |
| CASP6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265164 | M19R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CASP6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CASP6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CASP6_HUMAN | kinase -> substrate | RegPhos |
| NUAK1_HUMAN | CASP6_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| AAPK2_HUMAN | CASP6_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04210 | Apoptosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | TAS | molecular_function |
| GO:0006508 | proteolysis | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |
| GO:0004197 | cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0004197 | cysteine-type endopeptidase activity | IEA | molecular_function |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |