Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEK4_HUMAN
Description:NIMA-related kinase 4 [Source:HGNC Symbol;Acc:11399]
Location:chr3 p21.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S484LGSSDsPASASPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T580GKVDVtSTQKEHPRD; phosphoELM
Y216MNSLVyRIIEGPkinasePhosphoSitePlus
S243IRTMLsKRPEEPkinasePhosphoSitePlus
S661PARRLsSDCSVPhosphoSitePlus
S639SVRKAsLSVAGPhosphoSitePlus
S482RLLGSsDSPASPhosphoSitePlus
S377AKGRDsVSDGFPhosphoSitePlus
S608SEMSSsKDRPLPhosphoSitePlus
Y695KSDGDyGEGKGPhosphoSitePlus
Y319EGSQTyIMGEGPhosphoSitePlus
S563FAFQEsPPRFLPhosphoSitePlus; HPRD
S489SPASAsRVAGIPhosphoSitePlus
S634SSSGPsVRKASPhosphoSitePlus
S487SDSPAsASRVAPhosphoSitePlus
S474TILAHsNLRLLPhosphoSitePlus
S44LRNASsRERRAPkinasePhosphoSitePlus
S629SQEEMsSSGPSPhosphoSitePlus
S691SSTDKsDGDYGPhosphoSitePlus
S630QEEMSsSGPSVPhosphoSitePlus
T582VDVTStQKEAEHPRD; phosphoELM
S340SGLLKsPASLKPhosphoSitePlus
S631EEMSSsGPSVRPhosphoSitePlus
S43NLRNAsSRERRPkinasePhosphoSitePlus
S286K.NNIKNGDSQSK.PSysPTM 2.0

Dephosphorylation site
NEK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000233027R777KHPIColorectal Cancer17344846
ENSP00000233027T140ABIOMARTBreast Cancer21930507, 21930502
ENSP00000233027R777KGreenman2007Intestines Cancer17344846, 18428421
ENSP00000233027E422KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
NEK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NEK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK4_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANDX39A_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANEYA2_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANZN410_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANCSTFT_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANDHX32_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANZN496_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANTF2B_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANPOGZ_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANMAD1_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANMED28_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANDCR1B_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANEXOS7_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANDTX1_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANZN597_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANHNF6_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANNOL7_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANCPSF3_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANSMBT1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NEK4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23