Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRP1_HUMAN
Description:RAS guanyl releasing protein 1 (calcium and DAG-regulated) [Source:HGNC Symbol;Acc:9878]
Location:chr15 q14
Node attribute:PPI(target); PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S491QDGYIsQEEFEefhandPhosphoSitePlus
Y215SEHLTyLEFKSRasGEFPhosphoSitePlus
S694PFVLSsPRKTAPhosphoSitePlus
S198KKRKVsLLFDHPhosphoSitePlus
S732WENKDsLIKSKPhosphoSitePlus
S661SSQKIsLRLKRPhosphoSitePlus
T45SLAHItQFRMMPhosphoSitePlus
T184WSRKLtQRIKSPhosphoSitePlus
S657LMGVSsQKISLPhosphoSitePlus
S210EPEELsEHLTYRasGEFPhosphoSitePlus

Dephosphorylation site
GRP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000310244P34LCOSMICIntestines Cancer17932254
ENSP00000310244F226LCOSMICHead and Neck Cancer21798893
ENSP00000310244S314LCOSMICOvarian Cancer21720365
ENSP00000310244G654fs*11COSMICHead and Neck Cancer21798893

Differential expressed protein
GRP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLCG1_HUMANGRP1_HUMANotherKEGG
GRP1_HUMANRRAS2_HUMANotherKEGG
SOS1_HUMANGRP1_HUMANotherKEGG
IKKA_HUMANGRP1_HUMANotherKEGG
GRP1_HUMANRASH_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007265Ras protein signal transductionTASbiological_process
GO:0016020membraneTAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008289lipid bindingTASmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function


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