Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PKD1_HUMAN
Description:polycystic kidney disease 1 (autosomal dominant) [Source:HGNC Symbol;Acc:9008]
Location:chr16 p13.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2320FGPRGsSTVTIREJPhosphoSitePlus
T2414TFSNKtLVLDEREJPhosphoSitePlus
Y4237ATEDVyQLEQQPhosphoSitePlus
S2320FGPRGsSTVTIHPRD
S1108LTVLAsNAFENPKDPhosphoSitePlus
T2420LVLDEtTTSTGREJPhosphoSitePlus
S4263SSRGPsPGLRPPhosphoSitePlus
S3419GEGTLsWPDLLPhosphoSitePlus
T4285GVDLAtGPSRTPhosphoSitePlus
S2321GPRGSsTVTIPHPRD
S4251LQGRRsSRAPAPhosphoSitePlus
S4169RSSRGsKVSPDPhosphoSitePlus
S4252QGRRSsRAPAGPhosphoSitePlus
S4288LATGPsRTPLRPhosphoSitePlus; HPRD
S2164VLMRRsQRNYLPhosphoSitePlus
T2489VHALTtKVHFEREJPhosphoSitePlus
T2324GSSTVtIPRERREJPhosphoSitePlus
S2321GPRGSsTVTIPREJPhosphoSitePlus
T2488AVHALtTKVHFREJPhosphoSitePlus
T1692VLEAGtYHVQLPKDPhosphoSitePlus
T1861FPDAGtFSIRLPKDPhosphoSitePlus
Y2168RSQRNyLEAHVPhosphoSitePlus
S4287LATGPsRTPLRHPRD
Y2004GSRVAyAWYFSPKDPhosphoSitePlus
T3417PSGEGtLSWPDPhosphoSitePlus
S1684SGKGFsLTVLEPKDPhosphoSitePlus
T2324GSSTVtIPRERHPRD
S4166LPSRSsRGSKVPhosphoSitePlus
Y3143VGIMLyGVDSRPLATPhosphoSitePlus

Dephosphorylation site
PKD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262304T3629ICOSMICCentral Nervous System Neoplasms18772396
ENSP00000399501T3628IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000262304S2896FCOSMICSkin Cancer21984974
ENSP00000262304S1869FCOSMICSkin Cancer21984974
ENSP00000262304E2966QCOSMICHead and Neck Cancer21798893
ENSP00000262304G1860fs*89COSMICHead and Neck Cancer21798893
ENSP00000262304D3146ECOSMICSkin Cancer21984974
ENSP00000262304V3730MCOSMICCentral Nervous System Neoplasms21163964

Differential expressed protein
PKD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PKD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKD1_HUMANHSPB1_HUMANkinase -> substrateRegPhos
PKD1_HUMANKPCD1_HUMANkinase -> substrateRegPhos
PKD1_HUMANHDAC7_HUMANkinase -> substrateRegPhos
PKD1_HUMANPP14A_HUMANkinase -> substrateRegPhos
PKD1_HUMANRIN1_HUMANkinase -> substrateRegPhos
PKD1_HUMANPLCG1_HUMANkinase -> substrateRegPhos
PKD1_HUMANHDAC5_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
PKD1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0072287metanephric distal tubule morphogenesisIEPbiological_process
GO:0007160cell-matrix adhesionTASbiological_process
GO:0072164mesonephric tubule developmentIEPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007507heart developmentIEPbiological_process
GO:0043588skin developmentIEPbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0007161calcium-independent cell-matrix adhesionTASbiological_process
GO:0002133polycystin complexISScellular_component
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0072205metanephric collecting duct developmentIEPbiological_process
GO:0048806genitalia developmentIEPbiological_process
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0005929ciliumISScellular_component
GO:0007259JAK-STAT cascadeISSbiological_process
GO:0051216cartilage developmentIEPbiological_process
GO:0006611protein export from nucleusISSbiological_process
GO:0050982detection of mechanical stimulusISSbiological_process
GO:0005737cytoplasmISScellular_component
GO:0072237metanephric proximal tubule developmentIEPbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0060428lung epithelium developmentIEPbiological_process
GO:0042994cytoplasmic sequestering of transcription factorISSbiological_process
GO:0021915neural tube developmentIEPbiological_process
GO:0048754branching morphogenesis of a tubeIDAbiological_process
GO:0001892embryonic placenta developmentISSbiological_process
GO:0007156homophilic cell adhesionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusISScellular_component
GO:0072177mesonephric duct developmentIEPbiological_process
GO:0019904protein domain specific bindingIPImolecular_function
GO:0048565digestive tract developmentIEPbiological_process
GO:0060674placenta blood vessel developmentISSbiological_process
GO:0007050cell cycle arrestISSbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0021510spinal cord developmentIEPbiological_process
GO:0018105peptidyl-serine phosphorylationISSbiological_process
GO:0031512motile primary ciliumISScellular_component
GO:0005261cation channel activityISSmolecular_function
GO:0032092positive regulation of protein bindingISSbiological_process
GO:0072218metanephric ascending thin limb developmentIEPbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0001822kidney developmentISSbiological_process


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