| UniProt/SwissProt ID: | SP100_HUMAN |
| Description: | SP100 nuclear antigen [Source:HGNC Symbol;Acc:11206] |
| Location: | chr2 q37.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S419 | APAEAsSGALR | HPRD | |
| S445 | TWRIPsRKRRF | PhosphoSitePlus | |
| S410 | DFSESsEEEAP | PhosphoSitePlus; HPRD; phosphoELM | |
| T335 | DSEGStDVDEP | HPRD; phosphoELM | |
| S469 | LQETCsSSLRR | HPRD | |
| Y50 | DDRLLyDIVFK | HPRD | |
| S409 | HDFSEsSEEEA | PhosphoSitePlus; HPRD; phosphoELM | |
| S328 | IIVISsEDSEG | HPRD; phosphoELM | |
| S470 | QETCSsSLRRG | HPRD | |
| S18 | LNECIsPVANE | PhosphoSitePlus; HPRD; phosphoELM | |
| S157 | LPLQEsEEEER | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T467 | EELQEtCSSSL | HPRD | |
| S453 | RRFSSsDFSDL | PhosphoSitePlus; HPRD; phosphoELM | |
| T221 | AKRKDtTSDKD | PhosphoSitePlus | |
| S452 | KRRFSsSDFSD | PhosphoSitePlus; HPRD; phosphoELM | |
| S92 | KMFEDsQDSCR | Sp100 | PhosphoSitePlus |
| S471 | ETCSSsLRRGS | HPRD | |
| S334 | EDSEGsTDVDE | HPRD; phosphoELM | |
| S420 | PAEASsGALRS | HPRD | |
| T560 | PRKHLtLNNKV | PhosphoSitePlus | |
| S223 | RKDTTsDKDDS | PhosphoSitePlus | |
| S407 | QDHDFsESSEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S451 | RKRRFsSSDFS | PhosphoSitePlus; HPRD; phosphoELM | |
| S231 | DDSLGsQQTNE | PhosphoSitePlus | |
| Y752 | REMKTyIPPKG | HMG_box | PhosphoSitePlus |
| T197 | PSHAGtTPPEN | PhosphoSitePlus | |
| Y50 | DDRLLyDIVFK | Sp100 | PhosphoSitePlus |
| S459 | DFSDLsNGEEL | PhosphoSitePlus; HPRD; phosphoELM | |
| S327 | DIIVIsSEDSE | HPRD; phosphoELM | |
| S476 | SLRRGsGSQPQ | PhosphoSitePlus | |
| Y836 | KDIAAyRAKGK | HMG_box | PhosphoSitePlus |
| S362 | DNPLEsNDEKE | PhosphoSitePlus; HPRD | |
| S331 | ISSEDsEGSTD | HPRD; phosphoELM | |
| T222 | KRKDTtSDKDD | PhosphoSitePlus | |
| S180 | GTGENsFRSLT | PhosphoSitePlus | |
| T39 | LQRMFtEDQGV | PhosphoSitePlus | |
| S228 | SDKDDsLGSQQ | PhosphoSitePlus | |
| S389 | DFRKLsTFRES | PhosphoSitePlus | |
| S456 | SSSDFsDLSNG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y818 | ADKQFyEKKAA | HMG_box | PhosphoSitePlus |
| S394 | STFREsFKKRV | PhosphoSitePlus | |
| S171 | SGLQLsLEQGT | PhosphoSitePlus | |
| Dephosphorylation site |
| SP100_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000343023 | D136N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000264052 | Q602L | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000264052 | D136N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264052 | P265S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000343023 | V786L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000343023 | Q602* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000264052 | Q602* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000343023 | P265S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000343023 | V786L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264052 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.4 | 15169874 |
| Hyperphosphorylation site |
| SP100_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PIM1_HUMAN | SP100_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | SP100_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SP100_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0051271 | negative regulation of cellular component movement | IMP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0048384 | retinoic acid receptor signaling pathway | IC | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0034341 | response to interferon-gamma | IMP | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0006978 | DNA damage response, signal transduction by p53 cl | IDA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032897 | negative regulation of viral transcription | IDA | biological_process |
| GO:0043392 | negative regulation of DNA binding | IDA | biological_process |
| GO:0034399 | nuclear periphery | IDA | cellular_component |
| GO:0034097 | response to cytokine stimulus | IDA | biological_process |
| GO:0060337 | type I interferon-mediated signaling pathway | IC | biological_process |
| GO:0034340 | response to type I interferon | IDA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070087 | chromo shadow domain binding | IPI | molecular_function |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0042803 | protein homodimerization activity | IPI | molecular_function |
| GO:0043433 | negative regulation of sequence-specific DNA bindi | IDA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0005730 | nucleolus | IMP | cellular_component |
| GO:0051091 | positive regulation of sequence-specific DNA bindi | IDA | biological_process |
| GO:0060333 | interferon-gamma-mediated signaling pathway | IC | biological_process |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0032526 | response to retinoic acid | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |