| UniProt/SwissProt ID: | SOCS6_HUMAN |
| Description: | suppressor of cytokine signaling 6 [Source:HGNC Symbol;Acc:16833] |
| Location: | chr18 q22.2 |
| Node attribute: | phosphotase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y416 | SSDDRyLLSLS | SH2 | PhosphoSitePlus |
| S144 | LRPTNsEETCI | PhosphoSitePlus | |
| Y443 | GRFSFyEQPDV | SH2 | PhosphoSitePlus |
| S419 | DRYLLsLSFRS | SH2 | PhosphoSitePlus |
| Y223 | QDYIQyTVPLD | PhosphoSitePlus | |
| Y132 | LRSHHySPAPW | PhosphoSitePlus | |
| T142 | WPLRPtNSEET | PhosphoSitePlus | |
| T147 | TNSEEtCIKME | PhosphoSitePlus | |
| Y358 | GVARVyDSVQS | PhosphoSitePlus | |
| S405 | NVPDGsFLVRD | SH2 | PhosphoSitePlus |
| Y220 | LMPQDyIQYTV | PhosphoSitePlus | |
| Dephosphorylation site |
| SOCS6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000381034 | D306Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000381034 | D403H | COSMIC | Lung Cancer | 20668451 | ENSP00000381034 | R140Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000381034 | M526I | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SOCS6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SOCS6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SOCS6_HUMAN | INSR_HUMAN | phosphatase -> substrate | KEGG |
| STAT1_HUMAN | SOCS6_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| SOCS6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0040008 | regulation of growth | IEA | biological_process |
| GO:0001772 | immunological synapse | IDA | cellular_component |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0050868 | negative regulation of T cell activation | IEA | biological_process |
| GO:0009968 | negative regulation of signal transduction | IEA | biological_process |
| GO:0006952 | defense response | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0010498 | proteasomal protein catabolic process | IMP | biological_process |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |