Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOCS6_HUMAN
Description:suppressor of cytokine signaling 6 [Source:HGNC Symbol;Acc:16833]
Location:chr18 q22.2
Node attribute:phosphotase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y416SSDDRyLLSLSSH2PhosphoSitePlus
S144LRPTNsEETCIPhosphoSitePlus
Y443GRFSFyEQPDVSH2PhosphoSitePlus
S419DRYLLsLSFRSSH2PhosphoSitePlus
Y223QDYIQyTVPLDPhosphoSitePlus
Y132LRSHHySPAPWPhosphoSitePlus
T142WPLRPtNSEETPhosphoSitePlus
T147TNSEEtCIKMEPhosphoSitePlus
Y358GVARVyDSVQSPhosphoSitePlus
S405NVPDGsFLVRDSH2PhosphoSitePlus
Y220LMPQDyIQYTVPhosphoSitePlus

Dephosphorylation site
SOCS6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381034D306YBIOMARTBreast Cancer21930507, 21930502
ENSP00000381034D403HCOSMICLung Cancer20668451
ENSP00000381034R140QCOSMICOvarian Cancer21720365
ENSP00000381034M526IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
SOCS6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOCS6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOCS6_HUMANINSR_HUMANphosphatase -> substrateKEGG
STAT1_HUMANSOCS6_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
SOCS6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0040008regulation of growthIEAbiological_process
GO:0001772immunological synapseIDAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0050868negative regulation of T cell activationIEAbiological_process
GO:0009968negative regulation of signal transductionIEAbiological_process
GO:0006952defense responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010498proteasomal protein catabolic processIMPbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0016567protein ubiquitinationIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process


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