Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NAMPT_HUMAN
Description:nicotinamide phosphoribosyltransferase [Source:HGNC Symbol;Acc:30092]
Location:chr7 q22.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S398DLLNCsFKCSYNAPRTasePhosphoSitePlus; SysPTM
S17LLATDsYKVTHPhosphoSitePlus
T15NILLAtDSYKVPhosphoSitePlus
S338PVTENsKGYKLNAPRTasePhosphoSitePlus
Y87EAKDVyKEHFQHPRD
Y54LRKVKyEETVFPhosphoSitePlus
Y453GDLEEyGQDLLNAPRTasePhosphoSitePlus
Y34NTSKVySYFECPhosphoSitePlus; HPRD; phosphoELM
S472VTKSYsFDEIRPhosphoSitePlus
Y188LDGLEyKLHDFHPRD; phosphoELM
Y18LATDSyKVTHYPhosphoSitePlus
Y64FYGLQyILNKYPhosphoSitePlus
T335KKFPVtENSKGNAPRTasePhosphoSitePlus
Y69YILNKyLKGKVPhosphoSitePlus
Y175KILAKyLLETSPhosphoSitePlus
Y36SKVYSyFECREPhosphoSitePlus
Y188LDGLEyKLHDFNAPRTasePhosphoSitePlus
S398DLLNCsFKCSYHPRD; SysPTM
Y26THYKQyPPNTSPhosphoSitePlus
Y60EETVFyGLQYIPhosphoSitePlus

Dephosphorylation site
NAMPT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222553L176SHPIColorectal Cancer16959974
ENSP00000222553L176SSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000222553Gastric CancerMetastasiscell lineDown0.6517022644
ENSP00000222553Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000222553Hepatocellular CarcinomaMetastasiscell lineDown0.6219016532
ENSP00000222553Lung CancerNormal vs. CancertissueUp16342241
ENSP00000222553Gastric CancerMetastasiscell lineDown0.6517022644
ENSP00000222553Breast CancerNormal vs. Cancercell lineUp1020198662
ENSP00000222553Breast CancerNormal vs. Cancercell lineDown0.7620543960
ENSP00000222553Renal CancerNormal vs. CancertissueUp2.419610612
ENSP00000222553Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000222553Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp1.719513556

Hyperphosphorylation site
NAMPT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NAMPT_HUMANINSR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00760Nicotinate and nicotinamide metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006767water-soluble vitamin metabolic processTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0004514nicotinate-nucleotide diphosphorylase (carboxylatiIEAmolecular_function
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0047280nicotinamide phosphoribosyltransferase activityIEAmolecular_function
GO:0009435NAD biosynthetic processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005125cytokine activityTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0004516nicotinate phosphoribosyltransferase activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0006769nicotinamide metabolic processTASbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyIDAbiological_process
GO:0006766vitamin metabolic processTASbiological_process
GO:0019674NAD metabolic processTASbiological_process


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