| UniProt/SwissProt ID: | CBLC_HUMAN |
| Description: | Cbl proto-oncogene, E3 ubiquitin protein ligase C [Source:HGNC Symbol;Acc:15961] |
| Location: | chr19 q13.32 |
| Node attribute: | substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S43 | SVSPPsLRDLL | Cbl_N | PhosphoSitePlus |
| Y144 | FPGGKyCGHMY | Cbl_N | PhosphoSitePlus |
| T223 | FQPWPtLLKNW | Cbl_N2 | PhosphoSitePlus |
| Y402 | EAVSIyQFHGQ | PhosphoSitePlus | |
| S61 | REVAHsRRAAG | HPRD | |
| Y341 | EQLQLyWAMDS | PhosphoSitePlus | |
| S40 | PRLSVsPPSLR | HPRD; phosphoELM; SysPTM | |
| S40 | PRLSVsPPSLR | Cbl_N | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| CBLC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000270279 | P140S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000270279 | D34G | COSMIC | Ovarian Cancer | 20668451 | ENSP00000270279 | G301E | COSMIC | Lung Cancer | 20668451 | ENSP00000270279 | P444L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340250 | P398L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000270279 | S400fs*55 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000270279 | A166D | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| CBLC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CBLC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| INSR_HUMAN | CBLC_HUMAN | kinase -> substrate | KEGG |
| SH2B2_HUMAN | CBLC_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05220 | Chronic myeloid leukemia |
| hsa04660 | T cell receptor signaling pathway |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04630 | Jak-STAT signaling pathway |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa05200 | Pathways in cancer |
| hsa04144 | Endocytosis |
| hsa04910 | Insulin signaling pathway |
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001784 | phosphotyrosine binding | IDA | molecular_function |
| GO:0017124 | SH3 domain binding | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005154 | epidermal growth factor receptor binding | IDA | molecular_function |
| GO:0007175 | negative regulation of epidermal growth factor-act | IDA | biological_process |
| GO:0043407 | negative regulation of MAP kinase activity | IDA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0042059 | negative regulation of epidermal growth factor rec | IDA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0042787 | protein ubiquitination involved in ubiquitin-depen | IDA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |