Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CBLC_HUMAN
Description:Cbl proto-oncogene, E3 ubiquitin protein ligase C [Source:HGNC Symbol;Acc:15961]
Location:chr19 q13.32
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S43SVSPPsLRDLLCbl_NPhosphoSitePlus
Y144FPGGKyCGHMYCbl_NPhosphoSitePlus
T223FQPWPtLLKNWCbl_N2PhosphoSitePlus
Y402EAVSIyQFHGQPhosphoSitePlus
S61REVAHsRRAAGHPRD
Y341EQLQLyWAMDSPhosphoSitePlus
S40PRLSVsPPSLRHPRD; phosphoELM; SysPTM
S40PRLSVsPPSLRCbl_NPhosphoSitePlus; SysPTM

Dephosphorylation site
CBLC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000270279P140SCOSMICHead and Neck Cancer21984974
ENSP00000270279D34GCOSMICOvarian Cancer20668451
ENSP00000270279G301ECOSMICLung Cancer20668451
ENSP00000270279P444LCOSMICOvarian Cancer21720365
ENSP00000340250P398LTCGAOvarian Cancer21720365, 18772890
ENSP00000270279S400fs*55COSMICOvarian Cancer21720365
ENSP00000270279A166DCOSMICOvarian Cancer20668451

Differential expressed protein
CBLC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CBLC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INSR_HUMANCBLC_HUMANkinase -> substrateKEGG
SH2B2_HUMANCBLC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa04660T cell receptor signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04630Jak-STAT signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001784phosphotyrosine bindingIDAmolecular_function
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005154epidermal growth factor receptor bindingIDAmolecular_function
GO:0007175negative regulation of epidermal growth factor-actIDAbiological_process
GO:0043407negative regulation of MAP kinase activityIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0042059negative regulation of epidermal growth factor recIDAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component


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